Effect of increased intracranial pressure on blood flow through cerebral arteries and aneurysms -a fluid-structure interaction study

Show simple item record

dc.contributor Olcmen, Semih M.
dc.contributor Kim, Yonghyun
dc.contributor.advisor Unnikrishnan, Vinu U.
dc.contributor.author Syed, Hasson Basha Quadri
dc.contributor.other University of Alabama Tuscaloosa
dc.date.accessioned 2017-04-26T14:24:40Z
dc.date.available 2017-04-26T14:24:40Z
dc.date.issued 2016
dc.identifier.other u0015_0000001_0002224
dc.identifier.other SYED_alatus_0004M_12526
dc.identifier.uri http://ir.ua.edu/handle/123456789/3054
dc.description Electronic Thesis or Dissertation en_US
dc.description.abstract The pathological changes due to many cerebral diseases lead to increase in intracranial pressure (ICP), which is a life threatening condition especially in severe head injuries such as traumatic brain injury, hydrocephalus, sub arachnoid hemorrhage etc. Elevated intracranial pressure (ICP) is a major contributor to morbidity and mortality in severe head injuries. Maintaining the ICP within acceptable range is important to contain the failure of auto regulation which maintains and regulates adequate cerebral blood flow inside the brain. These increased intracranial pressures are found to significantly affect the Wall Shear Stresses (WSS) distribution in the artery, which is an important hemodynamic parameter and may lead to the formation, progression and rupture of cerebral aneurysms (pathological dilatations in cerebral arteries) which go unnoticed until a stage when they are severe. Earlier research on cerebral arteries and aneurysms involves using constant mean ICP values. Recent advancements in ICP monitoring techniques have led to measurement of the ICP waveform and by incorporating time varying ICP waveform in the analysis of cerebral arteries helps in better understanding their effects on wall deformation and shear stresses. To date, such a robust computational study on the effect of increasing intracranial pressures on the cerebral arterial walls and aneurysms has not been attempted to the best of our knowledge. In this work, fully coupled fluid structural interaction (FSI) simulations are carried out to investigate the effect of variation of intracranial pressure (ICP) waveforms on the cerebral arterial walls and aneurysms. Three time varying ICP waveforms and three constant ICP profiles acting on the cerebral arterial wall are analyzed in this work. It has been found that the arterial and aneurysmal walls experiences significant deformation depending on the time varying ICP waveforms, while the WSS changes at peak systole for all the ICP profiles. Also, the maximum wall shear stresses decreased with increase in ICP inside the aneurysm dome and the minimum area of WSS distribution increased. en_US
dc.format.extent 93 p.
dc.format.medium electronic
dc.format.mimetype application/pdf
dc.language English
dc.language.iso en_US
dc.publisher University of Alabama Libraries
dc.relation.ispartof The University of Alabama Electronic Theses and Dissertations
dc.relation.ispartof The University of Alabama Libraries Digital Collections
dc.relation.hasversion born digital
dc.rights All rights reserved by the author unless otherwise indicated. en_US
dc.subject Aerospace engineering
dc.subject Biomechanics
dc.title Effect of increased intracranial pressure on blood flow through cerebral arteries and aneurysms -a fluid-structure interaction study en_US
dc.type thesis
dc.type text
etdms.degree.department University of Alabama. Department of Aerospace Engineering and Mechanics
etdms.degree.discipline Aerospace Engineering
etdms.degree.grantor The University of Alabama
etdms.degree.level master's
etdms.degree.name M.S.

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


My Account