A comparison of mechanical models for the viscoelastic response of human breast carcinomas

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dc.contributor Unnikrishnan, Vinu U.
dc.contributor Todd, Beth A.
dc.contributor.advisor Mahmoodi, S. Nima
dc.contributor.author Carmichael, Benjamin Daniel
dc.contributor.other University of Alabama Tuscaloosa
dc.date.accessioned 2017-03-01T17:11:35Z
dc.date.available 2017-03-01T17:11:35Z
dc.date.issued 2014
dc.identifier.other u0015_0000001_0001714
dc.identifier.other Carmichael_alatus_0004M_12147
dc.identifier.uri https://ir.ua.edu/handle/123456789/2164
dc.description Electronic Thesis or Dissertation en_US
dc.description.abstract The mechanical response of a living cell is notoriously complicated. The complex, heterogeneous characteristics of cellular structure introduce difficulties that simple linear models of viscoelasticity cannot overcome, particularly at moderate indentation depths. Herein, a nano-scale stress-relaxation analysis performed with an Atomic Force Microscope reveals that isolated human breast cells do not exhibit simple exponential relaxation capable of being modeled by the Standard Linear Solid (SLS) model. Therefore, this work proposes the application of a progression of more sophisticated models that may extract the mechanical parameters from the entire relaxation response, improving upon existing physical techniques to probe isolated cells. The first model under consideration is the Generalized Maxwell (GM) model that distributes the response of the cell across multiple time scales in an attempt to replicate the interaction of subcellular components. The second is a fractional model that operates without a priori assumptions of the cell's internal structure and describes the fractional time-derivative dependence of the response. The results show an exceptional increase in conformance to the experimental data compared to that predicted by the SLS model. Both models excel at mapping the relaxation behavior of the cells that occurs within a few seconds of the initial force. This area is generally ignored with an SLS fit and therefore not included in most cell differentiation studies. The results of the GM model show a significant change in the mechanical properties of the first relaxation mode, which validates the necessity of the early behavior's inclusion. The FZ model preserves the distinctions highlighted in the SLS model, but also incorporates the disparity in the early-relaxation times seen in the GM model as a change in the composite relaxation time. en_US
dc.format.extent 62 p.
dc.format.medium electronic
dc.format.mimetype application/pdf
dc.language English
dc.language.iso en_US
dc.publisher University of Alabama Libraries
dc.relation.ispartof The University of Alabama Electronic Theses and Dissertations
dc.relation.ispartof The University of Alabama Libraries Digital Collections
dc.relation.hasversion born digital
dc.rights All rights reserved by the author unless otherwise indicated. en_US
dc.subject Biomechanics
dc.subject Mechanics
dc.title A comparison of mechanical models for the viscoelastic response of human breast carcinomas en_US
dc.type thesis
dc.type text
etdms.degree.department University of Alabama. Department of Mechanical Engineering
etdms.degree.discipline Mechanical Engineering
etdms.degree.grantor The University of Alabama
etdms.degree.level master's
etdms.degree.name M.S.

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