Evaluation of microstructure response under various loading and boundary conditions to aid in the establishment of a threshold criterion for mild traumatic brain injury

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dc.contributor Todd, Beth A.
dc.contributor Williams, Keith A.
dc.contributor Barkey, Mark E.
dc.contributor.advisor Shepard, W. Steve
dc.contributor.author Taylor, William Matthew
dc.date.accessioned 2017-03-01T16:24:20Z
dc.date.available 2017-03-01T16:24:20Z
dc.date.issued 2011
dc.identifier.other u0015_0000001_0000815
dc.identifier.other Taylor_alatus_0004M_10933
dc.identifier.uri https://ir.ua.edu/handle/123456789/1319
dc.description Electronic Thesis or Dissertation
dc.description.abstract In previous research studies, the geometric and elastic properties for a critical component of axon health, the microtubule (MT), have been determined using lateral indentation with the tip of an atomic force microscope (AFM). Although the response due to the indentations caused by the AFM was observed to be linear for most of the tests, forces greater than 300pN would result in a permanent irreversible collapse of the MT's structure. While the intent of those researchers was not to evaluate microtubule strength properties, that load can be used as a starting point to evaluate internal stress failure criterion for such structures. To that end, the current research is investigating MT strength by replicating the loading and boundary conditions in a finite element model. This work is an extension of previous work aimed at using this 300 pN point load to develop failure criteria for MTs under more realistic loading conditions. In the present work, modeling has been used to correlate the AFM point load response with the more realistic distributed loading conditions that would result during a brain injury event. Furthermore, the impact of nearby MTs on the stresses that occur under similar loading conditions has also examined. Correspondingly, models that include dynamic wave propagation through the microtubule were also studied. These results were used to analytically examine different loading conditions in order to equate various scenarios so that the determination of a stress threshold related to MT structural failure could more easily be examined in later work. The failure criterion determined in both cases would aid in evaluating brain injury studies that involve pressure wave propagation in whole-head finite element models, even when such models represent the white matter using homogeneous properties.
dc.format.extent 67 p.
dc.format.medium electronic
dc.format.mimetype application/pdf
dc.language English
dc.language.iso en_US
dc.publisher University of Alabama Libraries
dc.relation.ispartof The University of Alabama Electronic Theses and Dissertations
dc.relation.ispartof The University of Alabama Libraries Digital Collections
dc.relation.hasversion born digital
dc.rights All rights reserved by the author unless otherwise indicated.
dc.subject.other Nanoscience
dc.subject.other Mechanical engineering
dc.title Evaluation of microstructure response under various loading and boundary conditions to aid in the establishment of a threshold criterion for mild traumatic brain injury
dc.type thesis
dc.type text
etdms.degree.department University of Alabama. Dept. of Mechanical Engineering
etdms.degree.discipline Mechanical Engineering
etdms.degree.grantor The University of Alabama
etdms.degree.level master's
etdms.degree.name M.S.


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