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Synthesis and Characterization of Multifunctional Chitosan- MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery

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dc.contributor.authorKim, Dong-Hyun
dc.contributor.authorNikles, David E.
dc.contributor.authorBrazel, Christopher S.
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2023-09-28T19:19:36Z
dc.date.available2023-09-28T19:19:36Z
dc.date.issued2010
dc.description.abstractMultifunctional nanoparticles composed of MnFe2O4 were encapsulated in chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe2O4 to be used as an efficient MRI contrast agent for cancer diagnosis. This paper focuses on the synthesis and characterization of magnetic MnFe2O4 nanoparticles, their dispersion in water and their incorporation in chitosan, which serves as a drug carrier. The surface of the MnFe2O4 nanoparticles was modified with meso-2,3-di-mercaptosuccinic acid (DMSA) to develop stable aqueous dispersions. The nanoparticles were coated with chitosan, and the magnetic properties, heat generation and hydrodynamic size of chitosan-coated MnFe2O4 were evaluated for various linker concentrations and in a range of pH conditions.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationKim, D.-H., Nikles, D. E., & Brazel, C. S. (2010). Synthesis and Characterization of Multifunctional Chitosan- MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery. In Materials (Vol. 3, Issue 7, pp. 4051–4065). MDPI AG. https://doi.org/10.3390/ma3074051
dc.identifier.doi10.3390/ma3074051
dc.identifier.orcidhttps://orcid.org/0000-0001-6815-3319
dc.identifier.urihttps://ir.ua.edu/handle/123456789/11302
dc.languageEnglish
dc.language.isoen_US
dc.publisherMDPI
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectmultifunctional magnetic nanoparticles
dc.subjectchitosan
dc.subjectMnFe2O4 nanoparticles
dc.subjectmagnetic hyperthermia
dc.subjectdrug delivery
dc.subjectRELEASE
dc.subjectPOLYMERIZATION
dc.subjectChemistry, Physical
dc.subjectMaterials Science, Multidisciplinary
dc.subjectMetallurgy & Metallurgical Engineering
dc.subjectPhysics, Applied
dc.subjectPhysics, Condensed Matter
dc.titleSynthesis and Characterization of Multifunctional Chitosan- MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Deliveryen_US
dc.typeArticle
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