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The influence of surfactant on the propagation of a semi-infinite bubble through a liquid-filled compliant channel

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dc.contributor.authorHalpern, David
dc.contributor.authorGaver, Donald P., III
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherTulane University
dc.date.accessioned2023-09-28T19:38:48Z
dc.date.available2023-09-28T19:38:48Z
dc.date.issued2012
dc.description.abstractWe investigate the influence of a soluble surfactant on the steady-state motion of a finger of air through a compliant channel. This study provides a basic model from which to understand the fluid-structure interactions and physicochemical hydrodynamics of pulmonary airway reopening. Airway closure occurs in lung diseases such as respiratory distress syndrome and acute respiratory distress syndrome as a result of fluid accumulation and surfactant insufficiency. This results in 'compliant collapse' with the airway walls buckled and held in apposition by a liquid occlusion that blocks the passage of air. Airway reopening is essential to the recovery of adequate ventilation, but has been associated with ventilator-induced lung injury because of the exposure of airway epithelial cells to large interfacial flow-induced pressure gradients. Surfactant replacement is helpful in modulating this deleterious mechanical stimulus, but is limited in its effectiveness owing to slow surfactant adsorption. We investigate the effect of surfactant on micro-scale models of reopening by computationally modelling the steady two-dimensional motion of a semi-infinite bubble propagating through a liquid-filled compliant channel doped with soluble surfactant. Many dimensionless parameters affect reopening, but we primarily investigate how the reopening pressure p(b) depends upon the capillary number Ca (the ratio of viscous to surface tension forces), the adsorption depth parameter lambda (a bulk concentration parameter) and the bulk Peclet number Pe(b) (the ratio of bulk convection to diffusion). These studies demonstrate a dependence of p(b) on lambda, and suggest that a critical bulk concentration must be exceeded to operate as a low-surface-tension system. Normal and tangential stress gradients remain largely unaffected by physicochemical interactions - for this reason, further biological studies are suggested that will clarify the role of wall flexibility and surfactant on the protection of the lung from atelectrauma.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationHalpern, D., & Gaver III, D. P. (2012). The influence of surfactant on the propagation of a semi-infinite bubble through a liquid-filled compliant channel. In Journal of Fluid Mechanics (Vol. 698, pp. 125–159). Cambridge University Press (CUP). https://doi.org/10.1017/jfm.2012.66
dc.identifier.doi10.1017/jfm.2012.66
dc.identifier.orcidhttps://orcid.org/0000-0003-2255-156X
dc.identifier.orcidhttps://orcid.org/0000-0003-2255-156X
dc.identifier.urihttps://ir.ua.edu/handle/123456789/11671
dc.languageEnglish
dc.language.isoen_US
dc.publisherCambridge University Press
dc.subjectbiomedical flows
dc.subjectpulmonary fluid mechanics
dc.subjectFLUID PARTICLE INTERFACES
dc.subjectFLEXIBLE-WALLED CHANNEL
dc.subjectEPITHELIAL-CELL DAMAGE
dc.subjectMECHANICAL STRESSES
dc.subjectSTEADY PROPAGATION
dc.subjectPULSATILE MOTION
dc.subjectLUNG INJURY
dc.subjectMODEL
dc.subjectFLOW
dc.subjectTRANSPORT
dc.subjectMechanics
dc.subjectPhysics, Fluids & Plasmas
dc.titleThe influence of surfactant on the propagation of a semi-infinite bubble through a liquid-filled compliant channelen_US
dc.typeArticle
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