A Mixed-Effects Model of Associations Between Interleukin-6 and Hippocampal Volume

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10.1093geronaglab313.pdf (1.35 MB)

Date

2022

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Oxford University Press

Abstract

Previous studies report hippocampal volume loss can help predict conversion from normative aging to mild cognitive impairment to dementia. Additionally, a growing literature indicates that stress-related allostatic load may increase disease vulnerability. The current study examined the relationship between stress-related cytokines (ie, interleukin-6 [IL-6]), cognition as measured by Mini-Mental State Examination (MMSE) scores, and hippocampal volume. Mixed models were employed to examine both within- (across time) and between-subject effects of IL-6 and hippocampal volume on MMSE score among 566 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). The within-subject analysis found left hippocampal volume significantly (p = .009) predicted MMSE score. Between-subject analysis found the effect of IL-6 on MMSE was moderated by right hippocampal volume (p = .001). These results replicate previous findings and also extend prior work demonstrating stress-related cytokines may play a role in Alzheimer's disease progression.

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Keywords

Cognitive decline, Inflammation, Memory, Stress-related cytokines, MILD COGNITIVE IMPAIRMENT, ALZHEIMERS-DISEASE, STRESS, MEMORY, DEPRESSION, CHILDHOOD, DEMENTIA, HEALTHY, ATROPHY, MRI, Geriatrics & Gerontology, Gerontology

Citation

Harrell, E. R., Bui, C., & Newman, S. D. (2021). A Mixed-Effects Model of Associations Between Interleukin-6 and Hippocampal Volume. In D. G. Le Couteur (Ed.), The Journals of Gerontology: Series A (Vol. 77, Issue 4, pp. 683–688). Oxford University Press (OUP). https://doi.org/10.1093/gerona/glab313

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https://ir.ua.edu/handle/123456789/11798

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Research and Publications - Department of Psychology