Back to the future through the wormhole: Caenorhabditis elegans as a preclinical model

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dc.contributor.authorCaldwell, Guy A.
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherUniversity of Alabama Birmingham
dc.date.accessioned2023-09-29T12:44:53Z
dc.date.available2023-09-29T12:44:53Z
dc.date.issued2023
dc.description.abstractOn the 15th Anniversary of Disease Models & Mechanisms as a trailblazing venue for the dissemination of discoveries pertaining to human health involving model systems, we celebrate the journey of this journal, as mirrored through the evolution of research using the nematode roundworm, Caenorhabditis elegans. Driven by the exponential growth of genomic data, worms have advanced from a basic research tool to precise and elegant models for disease and have yielded substantive insights into numerous human disorders. A harbinger of functional genomic analysis since the inception of RNA interference screening, the directed application of C. elegans for identification of disease-modifying factors has revealed new pathways and therapeutic targets to accelerate translational outcomes. Together with advances in gene editing, worm models are now ushering in the era of precision medicine with characteristic expedience.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationCaldwell, G. A. (2023). Back to the future through the wormhole: Caenorhabditis elegans as a preclinical model. Disease Models & Mechanisms, 16(6). https://doi.org/10.1242/dmm.050333
dc.identifier.doi10.1242/dmm.050333
dc.identifier.urihttps://ir.ua.edu/handle/123456789/12338
dc.languageEnglish
dc.language.isoen_US
dc.publisherCompany of Biologists
dc.subjectCaenorhabditis elegans
dc.subjectPreclinical
dc.subjectWorms
dc.subjectGenetics
dc.subjectTOXICITY
dc.subjectCell Biology
dc.subjectPathology
dc.titleBack to the future through the wormhole: Caenorhabditis elegans as a preclinical modelen_US
dc.typeEditorial Material
dc.typetext

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