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Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth

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dc.contributor.authorRiquelme, Cecilia A.
dc.contributor.authorMagida, Jason A.
dc.contributor.authorHarrison, Brooke C.
dc.contributor.authorWall, Christopher E.
dc.contributor.authorMarr, Thomas G.
dc.contributor.authorSecor, Stephen M.
dc.contributor.authorLeinwand, Leslie A.
dc.contributor.otherUniversity of Colorado Boulder
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2023-10-02T15:14:27Z
dc.date.available2023-10-02T15:14:27Z
dc.date.issued2011
dc.description.abstractBurmese pythons display a marked increase in heart mass after a large meal. We investigated the molecular mechanisms of this physiological heart growth with the goal of applying this knowledge to the mammalian heart. We found that heart growth in pythons is characterized by myocyte hypertrophy in the absence of cell proliferation and by activation of physiological signal transduction pathways. Despite high levels of circulating lipids, the postprandial python heart does not accumulate triglycerides or fatty acids. Instead, there is robust activation of pathways of fatty acid transport and oxidation combined with increased expression and activity of superoxide dismutase, a cardioprotective enzyme. We also identified a combination of fatty acids in python plasma that promotes physiological heart growth when injected into either pythons or mice.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationRiquelme, C. A., Magida, J. A., Harrison, B. C., Wall, C. E., Marr, T. G., Secor, S. M., & Leinwand, L. A. (2011). Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth. In Science (Vol. 334, Issue 6055, pp. 528–531). American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/science.1210558
dc.identifier.doi10.1126/science.1210558
dc.identifier.orcidhttps://orcid.org/0000-0003-1470-4810
dc.identifier.urihttps://ir.ua.edu/handle/123456789/12445
dc.languageEnglish
dc.language.isoen_US
dc.publisherAmerican Association for the Advancement of Science
dc.subjectGENE-EXPRESSION
dc.subjectMYOCYTES
dc.subjectHYPERTROPHY
dc.subjectMOLURUS
dc.subjectPERFORMANCE
dc.subjectMETABOLISM
dc.subjectAPOPTOSIS
dc.subjectTISSUE
dc.subjectHEART
dc.subjectMODEL
dc.subjectMultidisciplinary Sciences
dc.titleFatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growthen_US
dc.typeArticle
dc.typetext

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