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Determining iron oxide nanoparticle heating efficiency and elucidating local nanoparticle temperature for application in agarose gel-based tumor model

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dc.contributor.authorShah, Rhythm R.
dc.contributor.authorDombrowsky, Alexander R.
dc.contributor.authorPaulson, Abigail L.
dc.contributor.authorJohnson, Margaret P.
dc.contributor.authorNikles, David E.
dc.contributor.authorBrazel, Christopher S.
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2023-09-28T19:11:28Z
dc.date.available2023-09-28T19:11:28Z
dc.date.issued2016
dc.description.abstractMagnetic iron oxide nanoparticles (MNPs) have been developed for magnetic fluid hyperthermia (MFH) cancer therapy, where cancer cells are treated through the heat generated by application of a high frequency magnetic field. This heat has also been proposed as a mechanism to trigger release of chemotherapy agents. In each of these cases, MNPs with optimal heating performance can be used to maximize therapeutic effect while minimizing the required dosage of MNPs. In this study, the heating efficiencies (or specific absorption rate, SAR) of two types of MNPs were evaluated experimentally and then predicted from their magnetic properties. MNPs were also incorporated in the core of poly(ethylene glycol-b-caprolactone) micelles, co-localized with rhodamine B fluorescent dye attached to polycaprolactone to monitor local, nanoscale temperatures during magnetic heating. Despite a relatively high SAR produced by these MNPs, no significant temperature rise beyond that observed in the bulk solution was measured by fluorescence in the core of the magnetic micelles. MNPs were also incorporated into a macro-scale agarose gel system that mimicked a tumor targeted by MNPs and surrounded by healthy tissues. The agarose-based tumor models showed that targeted MNPs can reach hyperthermia temperatures inside a tumor with a sufficient MNP concentration, while causing minimal temperature rise in the healthy tissue surrounding the tumor. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationShah, R. R., Dombrowsky, A. R., Paulson, A. L., Johnson, M. P., Nikles, D. E., & Brazel, C. S. (2016). Determining iron oxide nanoparticle heating efficiency and elucidating local nanoparticle temperature for application in agarose gel-based tumor model. In Materials Science and Engineering: C (Vol. 68, pp. 18–29). Elsevier BV. https://doi.org/10.1016/j.msec.2016.05.086
dc.identifier.doi10.1016/j.msec.2016.05.086
dc.identifier.orcidhttps://orcid.org/0000-0002-7640-850X
dc.identifier.orcidhttps://orcid.org/0000-0003-2463-5927
dc.identifier.urihttps://ir.ua.edu/handle/123456789/10990
dc.languageEnglish
dc.language.isoen_US
dc.publisherElsevier
dc.subjectHyperthermia
dc.subjectMagnetic heating
dc.subjectIron oxide nanoparticles
dc.subjectMagnetic field
dc.subjectPower generation
dc.subjectSpecific absorption rate
dc.subjectLocal nanoparticle temperature
dc.subjectAgarose gel tumor model
dc.subjectMAGNETIC HYPERTHERMIA
dc.subjectABSORPTION RATE
dc.subjectIN-VITRO
dc.subjectSIZE
dc.subjectFLUID
dc.subjectFIELD
dc.subjectCOMBINATION
dc.subjectRELEASE
dc.subjectSYSTEMS
dc.subjectIMPACT
dc.subjectMaterials Science, Biomaterials
dc.titleDetermining iron oxide nanoparticle heating efficiency and elucidating local nanoparticle temperature for application in agarose gel-based tumor modelen_US
dc.typeArticle
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