Semicontinuous sophorolipid fermentation using a novel bioreactor with dual ventilation pipes and dual sieve-plates coupled with a novel separation system

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dc.contributor.authorZhang, Yaguang
dc.contributor.authorJia, Dan
dc.contributor.authorSun, Wanqi
dc.contributor.authorYang, Xue
dc.contributor.authorZhang, Chuanbo
dc.contributor.authorZhao, Fanglong
dc.contributor.authorLu, Wenyu
dc.contributor.otherTianjin University
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2023-09-28T19:11:42Z
dc.date.available2023-09-28T19:11:42Z
dc.date.issued2018
dc.description.abstractSophorolipids (SLs) are biosurfactants with widespread applications. The yield and purity of SLs are two important factors to be considered during their commercial large-scale production. Notably, SL accumulation causes an increase in viscosity, decrease in dissolved oxygen and product inhibition in the fermentation medium. This inhibits the further production and purification of SLs. This describes the development of a novel integrated system for SL production using Candida albicans O-13-1. Semicontinuous fermentation was performed using a novel bioreactor with dual ventilation pipes and dual sieve-plates (DVDSB). SLs were separated and recovered using a newly designed two-stage separation system. After SL recovery, the fermentation broth containing residual glucose and oleic acid was recycled back into the bioreactor. This novel approach considerably alleviated the problem of product inhibition and accelerated the rate of substrate utilization. Production of SLs achieved was 477gl(-1), while their productivity was 1.59gl(-1)h(-1). Purity of SLs improved by 23.3%, from 60% to 74%, using DVDSB with the separation system. The conversion rate of carbon source increased from 0.5gg(-1) (in the batch fermentation) to 0.6gg(-1). These results indicated that the integrated system could improve the efficiency of production and purity of SLs.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationZhang, Y., Jia, D., Sun, W., Yang, X., Zhang, C., Zhao, F., & Lu, W. (2017). Semicontinuous sophorolipid fermentation using a novel bioreactor with dual ventilation pipes and dual sieve-plates coupled with a novel separation system. In Microbial Biotechnology (Vol. 11, Issue 3, pp. 455–464). Wiley. https://doi.org/10.1111/1751-7915.13028
dc.identifier.doi10.1111/1751-7915.13028
dc.identifier.urihttps://ir.ua.edu/handle/123456789/11022
dc.languageEnglish
dc.language.isoen_US
dc.publisherWiley
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBOMBICOLA ATCC 22214
dc.subjectSTARMERELLA-BOMBICOLA
dc.subjectCANDIDA-BOMBICOLA
dc.subjectSUGARCANE MOLASSES
dc.subjectCASTOR-OIL
dc.subjectHYDROLYSATE
dc.subjectBiotechnology & Applied Microbiology
dc.subjectMicrobiology
dc.titleSemicontinuous sophorolipid fermentation using a novel bioreactor with dual ventilation pipes and dual sieve-plates coupled with a novel separation systemen_US
dc.typeArticle
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