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CD200R/Foxp3-mediated signalling regulates microglial activation

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dc.contributor.authorYi, Min-Hee
dc.contributor.authorZhang, Enji
dc.contributor.authorKim, Jwa-Jin
dc.contributor.authorBaek, Hyunjung
dc.contributor.authorShin, Nara
dc.contributor.authorKim, Sena
dc.contributor.authorKim, Sang Ryong
dc.contributor.authorKim, Hang-Rae
dc.contributor.authorLee, Sung Joong
dc.contributor.authorPark, Jin Bong
dc.contributor.authorKim, Yonghyun
dc.contributor.authorKwon, O-Yu
dc.contributor.authorLee, Young Ho
dc.contributor.authorOh, Sang-Ha
dc.contributor.authorKim, Dong Woon
dc.contributor.otherChungnam National University
dc.contributor.otherUniversity of Texas Medical Branch Galveston
dc.contributor.otherYanbian University
dc.contributor.otherChungnam National University Hospital
dc.contributor.otherKyungpook National University
dc.contributor.otherSeoul National University (SNU)
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2023-10-02T15:17:32Z
dc.date.available2023-10-02T15:17:32Z
dc.date.issued2016
dc.description.abstractThe heterogeneity of microglial functions have either beneficial or detrimental roles in specific physiological or pathological environments. However, the details of what transcriptional mechanisms induce microglia to take beneficial phenotypes remain unknown. Here, we report that Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R). Foxp3 expression was up-regulated in microglia activated by excitotoxicity-induced hippocampal neuroinflammation. Suppression of CD200R prevented anti-inflammatory phenotype of microglia, but over-expression of Foxp3 enhanced it. Phosphorylation of STAT6, a downstream effector of CD200R, modulated transcription of Foxp3. Finally, CD200R/Foxp3-mediated signalling enhanced hippocampal neuronal viability and conferred a degree of neuroprotection, presumably by counteracting inducible nitric oxide synthase. We conclude that enhancement of Foxp3 through CD200R could be neuroprotective by targeting the microglia.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationYi, M.-H., Zhang, E., Kim, J.-J., Baek, H., Shin, N., Kim, S., Kim, S. R., Kim, H.-R., Lee, S. J., Park, J. B., Kim, Y., Kwon, O.-Y., Lee, Y. H., Oh, S.-H., & Kim, D. W. (2016). CD200R/Foxp3-mediated signalling regulates microglial activation. In Scientific Reports (Vol. 6, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/srep34901
dc.identifier.doi10.1038/srep34901
dc.identifier.orcidhttps://orcid.org/0000-0001-6344-1258
dc.identifier.orcidhttps://orcid.org/0000-0001-7691-1394
dc.identifier.orcidhttps://orcid.org/0000-0001-8238-2345
dc.identifier.orcidhttps://orcid.org/0000-0002-3983-6193
dc.identifier.orcidhttps://orcid.org/0000-0003-3734-5005
dc.identifier.orcidhttps://orcid.org/0000-0002-0081-945X
dc.identifier.urihttps://ir.ua.edu/handle/123456789/12593
dc.languageEnglish
dc.language.isoen_US
dc.publisherNature Portfolio
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCENTRAL-NERVOUS-SYSTEM
dc.subjectT-CELLS
dc.subjectIN-VIVO
dc.subjectCD200-DEFICIENT MICE
dc.subjectTRANSCRIPTION FACTOR
dc.subjectEXCITOTOXIC LESION
dc.subjectMOUSE HIPPOCAMPUS
dc.subjectMYELOID CELLS
dc.subjectFOXP3
dc.subjectRECEPTOR
dc.subjectMultidisciplinary Sciences
dc.titleCD200R/Foxp3-mediated signalling regulates microglial activationen_US
dc.typeArticle
dc.typetext

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