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Patterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorder

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dc.contributor.authorChannell, Marie Moore
dc.contributor.authorPhillips, B. Allyson
dc.contributor.authorLoveall, Susan J.
dc.contributor.authorConners, Frances A.
dc.contributor.authorBussanich, Paige M.
dc.contributor.authorKlinger, Laura Grofer
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherUniversity of California Davis
dc.contributor.otherUniversity of Kansas
dc.contributor.otherUniversity of Wisconsin Madison
dc.contributor.otherUniversity of North Carolina
dc.contributor.otherUniversity of North Carolina Chapel Hill
dc.date.accessioned2023-09-28T22:05:26Z
dc.date.available2023-09-28T22:05:26Z
dc.date.issued2015
dc.description.abstractBackground: Prevalence estimates of autism spectrum disorder (ASD) in Down syndrome (DS) are highly varied. This variation is partly due to the difficulty of screening for and diagnosing comorbid ASD in individuals with a syndrome that carries its own set of social communicative and behavioral difficulties that are not well documented. The aim of this study was to identify the typical range of social communicative impairments observed in children, adolescents, and young adults with DS who do not have comorbid ASD. Methods: We examined patterns of scores from the five subscales of the Social Responsiveness Scale (SRS) in 46 individuals with DS (ages 10-21 years) without comorbid ASD relative to the published normative sample. We also explored the correlations between SRS symptomatology and age, nonverbal cognition, and receptive language. Results: SRS scores were elevated (i.e., more ASD symptoms endorsed), with mean scores falling into the clinically significant range. Analysis by subscale revealed a specific pattern, with Autistic Mannerisms and Social Cognition scores significantly more elevated than Social Communication scores, which were significantly more elevated than Social Awareness and Social Motivation scores. Correlations between SRS scores and the other measures varied by subscale. Conclusions: General elevated ASD symptomatology on the SRS indicates the need for developing population-based norms specific to DS. The pattern of scores across subscales should inform clinicians of the typical range of behaviors observed in DS so that individuals with atypical patterns of behavior can be more easily identified and considered for a full ASD evaluation.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationChannell, M. M., Phillips, B. A., Loveall, S. J., Conners, F. A., Bussanich, P. M., & Klinger, L. G. (2015). Patterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorder. In Journal of Neurodevelopmental Disorders (Vol. 7, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/1866-1955-7-5
dc.identifier.doi10.1186/1866-1955-7-5
dc.identifier.orcidhttps://orcid.org/0000-0002-3851-8433
dc.identifier.urihttps://ir.ua.edu/handle/123456789/12331
dc.languageEnglish
dc.language.isoen_US
dc.publisherBMC
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDown syndrome
dc.subjectAutism spectrum disorder
dc.subjectComorbidity
dc.subjectSocial communication
dc.subjectIntellectual disability
dc.subjectSYNDROME POPULATION PREVALENCE
dc.subjectCHILDREN
dc.subjectQUESTIONNAIRE
dc.subjectClinical Neurology
dc.subjectNeurosciences
dc.titlePatterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorderen_US
dc.typeArticle
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