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Identification of an integrated stress and growth response signaling switch that directs vertebrate intestinal regeneration

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dc.contributor.authorWestfall, Aundrea K.
dc.contributor.authorPerry, Blair W.
dc.contributor.authorKamal, Abu H. M.
dc.contributor.authorHales, Nicole R.
dc.contributor.authorKay, Jarren C.
dc.contributor.authorSapkota, Madhab
dc.contributor.authorSchield, Drew R.
dc.contributor.authorPellegrino, Mark W.
dc.contributor.authorSecor, Stephen M.
dc.contributor.authorChowdhury, Saiful M.
dc.contributor.authorCastoe, Todd A.
dc.contributor.otherUniversity of Texas Arlington
dc.contributor.otherBaylor College of Medicine
dc.contributor.otherUniversity of North Texas Denton
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherUniversity of Texas Southwestern Medical Center Dallas
dc.date.accessioned2023-09-28T19:11:37Z
dc.date.available2023-09-28T19:11:37Z
dc.date.issued2022
dc.description.abstractBackground: Snakes exhibit extreme intestinal regeneration following months-long fasts that involves unparalleled increases in metabolism, function, and tissue growth, but the specific molecular control of this process is unknown. Understanding the mechanisms that coordinate these regenerative phenotypes provides valuable opportunities to understand critical pathways that may control vertebrate regeneration and novel perspectives on vertebrate regenerative capacities. Results: Here, we integrate a comprehensive set of phenotypic, transcriptomic, proteomic, and phosphoproteomic data from boa constrictors to identify the mechanisms that orchestrate shifts in metabolism, nutrient uptake, and cellular stress to direct phases of the regenerative response. We identify specific temporal patterns of metabolic, stress response, and growth pathway activation that direct regeneration and provide evidence for multiple key central regulatory molecules kinases that integrate these signals, including major conserved pathways like mTOR signaling and the unfolded protein response. Conclusion: Collectively, our results identify a novel switch-like role of stress responses in intestinal regeneration that forms a primary regulatory hub facilitating organ regeneration and could point to potential pathways to understand regenerative capacity in vertebrates.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationWestfall, A. K., Perry, B. W., Kamal, A. H. M., Hales, N. R., Kay, J. C., Sapkota, M., Schield, D. R., Pellegrino, M. W., Secor, S. M., Chowdhury, S. M., & Castoe, T. A. (2022). Identification of an integrated stress and growth response signaling switch that directs vertebrate intestinal regeneration. In BMC Genomics (Vol. 23, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12864-021-08226-5
dc.identifier.doi10.1186/s12864-021-08226-5
dc.identifier.orcidhttps://orcid.org/0000-0002-8639-4623
dc.identifier.orcidhttps://orcid.org/0000-0001-6750-0729
dc.identifier.orcidhttps://orcid.org/0000-0003-4849-4831
dc.identifier.urihttps://ir.ua.edu/handle/123456789/11014
dc.languageEnglish
dc.language.isoen_US
dc.publisherBMC
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectmTOR
dc.subjectNRF2
dc.subjectPhosphoproteomics
dc.subjectRNAseq
dc.subjectUnfolded protein response
dc.subjectPROTEIN-KINASE CK2
dc.subjectBURMESE PYTHON
dc.subjectGENE-EXPRESSION
dc.subjectCANCER CELLS
dc.subjectZEBRAFISH
dc.subjectCYTOSCAPE
dc.subjectPHOSPHORYLATION
dc.subjectINFLAMMATION
dc.subjectNEUROGENESIS
dc.subjectENVIRONMENT
dc.subjectBiotechnology & Applied Microbiology
dc.subjectGenetics & Heredity
dc.titleIdentification of an integrated stress and growth response signaling switch that directs vertebrate intestinal regenerationen_US
dc.typeArticle
dc.typetext

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