Engineering the pre-metastatic niche

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dc.contributor.authorAguado, Brian A.
dc.contributor.authorBushnell, Grace G.
dc.contributor.authorRao, Shreyas S.
dc.contributor.authorJeruss, Jacqueline S.
dc.contributor.authorShea, Lonnie D.
dc.contributor.otherNorthwestern University
dc.contributor.otherUniversity of Michigan
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2023-09-28T19:11:44Z
dc.date.available2023-09-28T19:11:44Z
dc.date.issued2017
dc.description.abstractThe pre-metastatic niche -the accumulation of aberrant immune cells and extracellular-matrix proteins in target organs primes the initially healthy organ microenvironment and renders it amenable for subsequent colonization by metastatic cancer cells. By attracting metastatic cells, mimics of the pre-metastatic niche offer both diagnostic and therapeutic potential. However, deconstructing the complexity of the niche by identifying the interactions between cell populations as well as the mediatory roles of the immune system, soluble factors, extracellular-matrix proteins and stromal cells has proved challenging. Experimental models are needed to recapitulate niche-population biology in situ and to mediate in vivo tumour-cell homing, colonization and proliferation. In this Review, we outline the biology of the pre-metastatic niche and discuss advances in the engineering of niche-mimicking biomaterials that regulate the behaviour of tumour cells at an implant site. Such 'oncomaterials' offer strategies for the early detection of metastatic events, the inhibition of the formation of the pre-metastatic niche and the attenuation of metastatic progression.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationAguado, B. A., Bushnell, G. G., Rao, S. S., Jeruss, J. S., & Shea, L. D. (2017). Engineering the pre-metastatic niche. In Nature Biomedical Engineering (Vol. 1, Issue 6). Springer Science and Business Media LLC. https://doi.org/10.1038/s41551-017-0077
dc.identifier.doi10.1038/s41551-017-0077
dc.identifier.orcidhttps://orcid.org/0000-0002-8891-803X
dc.identifier.urihttps://ir.ua.edu/handle/123456789/11026
dc.languageEnglish
dc.language.isoen_US
dc.publisherNature Portfolio
dc.subjectBREAST-CANCER METASTASIS
dc.subjectCIRCULATING TUMOR-CELLS
dc.subjectIN-VITRO MODEL
dc.subjectEXTRACELLULAR-MATRIX
dc.subjectFUCOSYLATED HAPTOGLOBIN
dc.subjectIMPLANTABLE SCAFFOLDS
dc.subjectBIOLOGICAL-PROPERTIES
dc.subjectSUPPRESSOR-CELLS
dc.subjectIMMUNE-RESPONSES
dc.subjectLUNG METASTASIS
dc.subjectEngineering, Biomedical
dc.titleEngineering the pre-metastatic nicheen_US
dc.typeReview
dc.typetext

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