Deletion of U(L)21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle

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dc.contributor.authorMbong, Ekaette F.
dc.contributor.authorWoodley, Lucille
dc.contributor.authorFrost, Elizabeth
dc.contributor.authorBaines, Joel D.
dc.contributor.authorDuffy, Carol
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherCornell University
dc.date.accessioned2023-10-02T15:14:24Z
dc.date.available2023-10-02T15:14:24Z
dc.date.issued2012
dc.description.abstractThe herpes simplex virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U(L)21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of U(L)21 results in a delay early in the HSV-1 replication cycle.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationMbong, E. F., Woodley, L., Frost, E., Baines, J. D., & Duffy, C. (2012). Deletion of U L 21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle. In Journal of Virology (Vol. 86, Issue 12, pp. 7003–7007). American Society for Microbiology. https://doi.org/10.1128/jvi.00411-12
dc.identifier.doi10.1128/JVI.00411-12
dc.identifier.orcidhttps://orcid.org/0000-0002-3071-2303
dc.identifier.urihttps://ir.ua.edu/handle/123456789/12439
dc.languageEnglish
dc.language.isoen_US
dc.publisherAmerican Society of Microbiology
dc.subjectREGULATORY PROTEIN ICP27
dc.subjectTEGUMENT PROTEIN
dc.subjectVIRION PROTEIN
dc.subjectCULTURED-CELLS
dc.subjectGENE-PRODUCT
dc.subjectTYPE-1
dc.subjectIDENTIFICATION
dc.subjectPOLYPEPTIDE
dc.subjectENCODES
dc.subjectMUTANT
dc.subjectVirology
dc.titleDeletion of U(L)21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycleen_US
dc.typeArticle
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