Deletion of U(L)21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle

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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
American Society of Microbiology
Abstract

The herpes simplex virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U(L)21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of U(L)21 results in a delay early in the HSV-1 replication cycle.

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Keywords
REGULATORY PROTEIN ICP27, TEGUMENT PROTEIN, VIRION PROTEIN, CULTURED-CELLS, GENE-PRODUCT, TYPE-1, IDENTIFICATION, POLYPEPTIDE, ENCODES, MUTANT, Virology
Citation
Mbong, E. F., Woodley, L., Frost, E., Baines, J. D., & Duffy, C. (2012). Deletion of U L 21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle. In Journal of Virology (Vol. 86, Issue 12, pp. 7003–7007). American Society for Microbiology. https://doi.org/10.1128/jvi.00411-12