Homeotic functions of the Teashirt transcription factor during adult Drosophila development

dc.contributor.authorWang, Wei
dc.contributor.authorTindell, Neil
dc.contributor.authorYan, Shun
dc.contributor.authorYoder, John H.
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2023-10-02T15:18:16Z
dc.date.available2023-10-02T15:18:16Z
dc.date.issued2013
dc.description.abstractDuring Drosophila development region-specific regulation of target genes by Hox proteins is modulated by genetic interactions with various cofactors and genetic collaborators. During embryogenesis one such modulator of Hox target specificity is the zinc-finger transcription factor Teashirt (Tsh) that is expressed in the developing trunk and cooperatively functions with trunk-specific Hox proteins to promote appropriate segment fate. This embryonic function of Tsh is characterized as homeotic since loss of embryonic Tsh activity leads to transformation of trunk segments toward head identity. In addition to this embryonic homeotic role, Tsh also performs vital Hox-independent functions through patterning numerous embryonic, larval and adult structures. Here we address whether the homeotic function of Tsh is maintained throughout development by investigating its contribution to patterning the adult abdomen. We show that Tsh is expressed throughout the developing abdomen and that this expression is dependent on the three Bithorax Hox proteins Ultrabithorax, Abdominal-A and Abdominal-B. Conditional reduction of Tsh activity during pupation reveals broad homeotic roles for this transcription factor throughout the adult abdomen. Additionally we show that, as during embryogenesis, the tsh paralog tiptop (tio) plays a partially redundant role in this homeotic activity. (C) 2012. Published by The Company of Biologists Ltd.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationWang, W., Tindell, N., Yan, S., & Yoder, J. H. (2012). Homeotic functions of the Teashirt transcription factor during adult Drosophila development. In Biology Open (Vol. 2, Issue 1, pp. 18–29). The Company of Biologists. https://doi.org/10.1242/bio.20122915
dc.identifier.doi10.1242/bio.20122915
dc.identifier.orcidhttps://orcid.org/0000-0002-9999-0360
dc.identifier.orcidhttps://orcid.org/0000-0001-8994-5542
dc.identifier.orcidhttps://orcid.org/0000-0001-9511-3611
dc.identifier.urihttps://ir.ua.edu/handle/123456789/12617
dc.languageEnglish
dc.language.isoen_US
dc.publisherCompany of Biologists
dc.rights.licenseAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectDrosophila
dc.subjectHomeotic
dc.subjectHox
dc.subjectTeashirt
dc.subjectSegmentation
dc.subjectBiology
dc.titleHomeotic functions of the Teashirt transcription factor during adult Drosophila developmenten_US
dc.typeArticle
dc.typetext
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