Functional Links Between A beta Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

dc.contributor.authorTreusch, Sebastian
dc.contributor.authorHamamichi, Shusei
dc.contributor.authorGoodman, Jessica L.
dc.contributor.authorMatlack, Kent E. S.
dc.contributor.authorChung, Chee Yeun
dc.contributor.authorBaru, Valeriya
dc.contributor.authorShulman, Joshua M.
dc.contributor.authorParrado, Antonio
dc.contributor.authorBevis, Brooke J.
dc.contributor.authorValastyan, Julie S.
dc.contributor.authorHan, Haesun
dc.contributor.authorLindhagen-Persson, Malin
dc.contributor.authorReiman, Eric M.
dc.contributor.authorEvans, Denis A.
dc.contributor.authorBennett, David A.
dc.contributor.authorOlofsson, Anders
dc.contributor.authorDeJager, Philip L.
dc.contributor.authorTanzi, Rudolph E.
dc.contributor.authorCaldwell, Kim A.
dc.contributor.authorCaldwell, Guy A.
dc.contributor.authorLindquist, Susan
dc.contributor.otherMassachusetts Institute of Technology (MIT)
dc.contributor.otherWhitehead Institute
dc.contributor.otherHoward Hughes Medical Institute
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherHarvard University
dc.contributor.otherBrigham & Women's Hospital
dc.contributor.otherHarvard Medical School
dc.contributor.otherBroad Institute
dc.contributor.otherMassachusetts General Hospital
dc.contributor.otherUmea University
dc.contributor.otherTranslational Genomics Research Institute
dc.contributor.otherUniversity of Arizona
dc.contributor.otherBanner Research
dc.contributor.otherBanner Health
dc.contributor.otherBanner Alzheimer's Institute
dc.contributor.otherRush University
dc.date.accessioned2023-10-02T15:14:26Z
dc.date.available2023-10-02T15:14:26Z
dc.date.issued2011
dc.description.abstractA beta (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled A beta toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers identified the yeast homolog of phosphatidylinositol binding clathrin assembly protein (PICALM) and other endocytic factors connected to AD whose relationship to A beta was previously unknown. The factors identified in yeast modified A beta toxicity in glutamatergic neurons of Caenorhabditis elegans and in primary rat cortical neurons. In yeast, A beta impaired the endocytic trafficking of a plasma membrane receptor, which was ameliorated by endocytic pathway factors identified in the yeast screen. Thus, links between A beta, endocytosis, and human AD risk factors can be ascertained with yeast as a model system.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationTreusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E. S., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., Han, H., Lindhagen-Persson, M., Reiman, E. M., Evans, D. A., Bennett, D. A., Olofsson, A., DeJager, P. L., Tanzi, R. E., Caldwell, K. A., … Lindquist, S. (2011). Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer’s Disease Risk Factors in Yeast. In Science (Vol. 334, Issue 6060, pp. 1241–1245). American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/science.1213210
dc.identifier.doi10.1126/science.1213210
dc.identifier.orcidhttps://orcid.org/0000-0002-7032-1454
dc.identifier.orcidhttps://orcid.org/0000-0003-1580-6122
dc.identifier.orcidhttps://orcid.org/0000-0002-8283-9090
dc.identifier.urihttps://ir.ua.edu/handle/123456789/12442
dc.languageEnglish
dc.language.isoen_US
dc.publisherAmerican Association for the Advancement of Science
dc.subjectGENOME-WIDE ASSOCIATION
dc.subjectALPHA-SYNUCLEIN
dc.subjectSACCHAROMYCES-CEREVISIAE
dc.subjectENDOPLASMIC-RETICULUM
dc.subjectIDENTIFIES VARIANTS
dc.subjectCOMMON VARIANTS
dc.subjectPEPTIDE
dc.subjectOLIGOMERS
dc.subjectMEMBRANE
dc.subjectCELLS
dc.subjectMultidisciplinary Sciences
dc.titleFunctional Links Between A beta Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeasten_US
dc.typeArticle
dc.typetext
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
10.1126science.1213210.pdf
Size:
8.57 MB
Format:
Adobe Portable Document Format