Synthesis and application of sterically flexible and water-soluble phosphine ligands in palladium catalysis

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dc.contributorJennings, Michael P.
dc.contributorBlackstock, Silas C.
dc.contributorRupar, Paul A.
dc.contributorDolliver, Debra D.
dc.contributor.advisorShaughnessy, Kevin H.
dc.contributor.authorMoore, Jane Nathanielle
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2017-03-01T17:08:51Z
dc.date.available2017-03-01T17:08:51Z
dc.date.issued2014
dc.descriptionElectronic Thesis or Dissertationen_US
dc.description.abstractThe need for more environmentally benign and sustainable chemical processes is currently a widely recognized motivation in chemical research. One area that has been of particular interest to our research group is the development of biphasic and aqueous phase systems for palladium catalysis. My research at The University of Alabama has focused on the design and synthesis of water-soluble phosphines for application in aqueous and biphasic palladium catalysis. Our group, through collaboration with the Dixon and Rogers groups, seeks also to better understand how phosphine ligand structure influences catalysis in order to design more effective systems. My work began with the study of the influence of flexible, electron-rich phosphine substituents such as the neopentyl and benzyl groups on catalyst activity, particularly for the Suzuki coupling of sterically hindered substrates. I have also synthesized two new water-soluble phosphine ligands that utilize two sterically hindered, electron-rich alkyl groups (di-tert-butyl or di-1-adamantyl) in conjunction with a flexible benzyl moiety, made water soluble through addition of an anionic sulfonate group. Both of the new ligands have shown moderate activity in Suzuki and Sonogashira coupling reactions. Through collaboration with the Hartman group, the ability to recycle a water-solubilized palladium-phosphine catalyst in biphasic microflow systems is being studied. Additionally, work has begun to extend the application of water-soluble phosphine ligands to other palladium catalyzed reactions, such as direct arylations.en_US
dc.format.extent336 p.
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.otheru0015_0000001_0001596
dc.identifier.otherMoore_alatus_0004D_11984
dc.identifier.urihttps://ir.ua.edu/handle/123456789/2050
dc.languageEnglish
dc.language.isoen_US
dc.publisherUniversity of Alabama Libraries
dc.relation.hasversionborn digital
dc.relation.ispartofThe University of Alabama Electronic Theses and Dissertations
dc.relation.ispartofThe University of Alabama Libraries Digital Collections
dc.rightsAll rights reserved by the author unless otherwise indicated.en_US
dc.subjectChemistry
dc.subjectOrganic chemistry
dc.titleSynthesis and application of sterically flexible and water-soluble phosphine ligands in palladium catalysisen_US
dc.typethesis
dc.typetext
etdms.degree.departmentUniversity of Alabama. Department of Chemistry
etdms.degree.disciplineChemistry
etdms.degree.grantorThe University of Alabama
etdms.degree.leveldoctoral
etdms.degree.namePh.D.
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