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Impact of magnetic field parameters and iron oxide nanoparticle properties on heat generation for use in magnetic hyperthermia

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dc.contributor.authorShah, Rhythm R.
dc.contributor.authorDavis, Todd P.
dc.contributor.authorGover, Amanda L.
dc.contributor.authorNikles, David E.
dc.contributor.authorBrazel, Christopher S.
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2023-09-28T19:34:31Z
dc.date.available2023-09-28T19:34:31Z
dc.date.issued2015
dc.description.abstractHeating of nanoparticles (NPs) using an AC magnetic field depends on several factors, and optimization of these parameters can improve the efficiency of heat generation for effective cancer therapy while administering a low NP treatment dose. This study investigated magnetic field strength and frequency, NP size, NP concentration, and solution viscosity as important parameters that impact the heating efficiency of iron oxide NPs with magnetite (Fe3O4) and maghemite (gamma-Fe2O3) crystal structures. Heating efficiencies were determined for each experimental setting, with specific absorption rates (SARs) ranging from 3.7 to 325.9 W/g Fe. Magnetic heating was conducted on iron oxide NPs synthesized in our laboratories (with average core sizes of 8, 11, 13, and 18 nm), as well as commercially-available iron oxides (with average core sizes of 8, 9, and 16 nm). The experimental magnetic coil system made it possible to isolate the effect of magnetic field parameters and independently study the effect on heat generation. The highest SAR values were found for the 18 am synthesized particles and the maghemite nanopowder. Magnetic field strengths were applied in the range of 15.1-47.7 kA/m, with field frequencies ranging from 123 to 430 kHz. The best heating was observed for the highest field strengths and frequencies tested, with results following trends predicted by the Rosensweig equation. An increase in solution viscosity led to lower heating rates in nanoparticle solutions, which can have significant implications for the application of magnetic fluid hyperthermia in vivo. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationShah, R. R., Davis, T. P., Glover, A. L., Nikles, D. E., & Brazel, C. S. (2015). Impact of magnetic field parameters and iron oxide nanoparticle properties on heat generation for use in magnetic hyperthermia. In Journal of Magnetism and Magnetic Materials (Vol. 387, pp. 96–106). Elsevier BV. https://doi.org/10.1016/j.jmmm.2015.03.085
dc.identifier.doi10.1016/j.jmmm.2015.03.085
dc.identifier.urihttps://ir.ua.edu/handle/123456789/11460
dc.languageEnglish
dc.language.isoen_US
dc.publisherElsevier
dc.subjectMagnetic fluid hyperthermia
dc.subjectIron oxide nanoparticles
dc.subjectMagnetic field strength
dc.subjectMagnetic field frequency
dc.subjectSpecific absorption rate
dc.subjectIN-VIVO
dc.subjectSIZE
dc.subjectFLUID
dc.subjectABSORPTION
dc.subjectPARTICLES
dc.subjectTUMORS
dc.subjectMaterials Science, Multidisciplinary
dc.subjectPhysics, Condensed Matter
dc.titleImpact of magnetic field parameters and iron oxide nanoparticle properties on heat generation for use in magnetic hyperthermiaen_US
dc.typeArticle
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