Young Adults with a Parent with Dementia Show Early Abnormalities in Brain Activity and Brain Volume in the Hippocampus: A Matched Case-Control Study

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dc.contributor.authorMcDonough, Ian M.
dc.contributor.authorMayhugh, Christopher
dc.contributor.authorMoore, Mary Katherine
dc.contributor.authorBrasfield, Mikenzi B.
dc.contributor.authorLetang, Sarah K.
dc.contributor.authorMadan, Christopher R.
dc.contributor.authorAllen, Rebecca S.
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherUniversity of Nottingham
dc.date.accessioned2023-09-28T22:04:39Z
dc.date.available2023-09-28T22:04:39Z
dc.date.issued2022
dc.description.abstractHaving a parent with Alzheimer's disease (AD) and related dementias confers a risk for developing these types of neurocognitive disorders in old age, but the mechanisms underlying this risk are understudied. Although the hippocampus is often one of the earliest brain regions to undergo change in the AD process, we do not know how early in the lifespan such changes might occur or whether they differ early in the lifespan as a function of family history of AD. Using a rare sample, young adults with a parent with late-onset dementia, we investigated whether brain abnormalities could already be detected compared with a matched sample. Moreover, we employed simple yet novel techniques to characterize resting brain activity (mean and standard deviation) and brain volume in the hippocampus. Young adults with a parent with dementia showed greater resting mean activity and smaller volumes in the left hippocampus compared to young adults without a parent with dementia. Having a parent with AD or a related dementia was associated with early aberrations in brain function and structure. This early hippocampal dysfunction may be due to aberrant neural firing, which may increase the risk for a diagnosis of dementia in old age.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationMcDonough, I. M., Mayhugh, C., Moore, M. K., Brasfield, M. B., Letang, S. K., Madan, C. R., & Allen, R. S. (2022). Young Adults with a Parent with Dementia Show Early Abnormalities in Brain Activity and Brain Volume in the Hippocampus: A Matched Case-Control Study. In Brain Sciences (Vol. 12, Issue 4, p. 496). MDPI AG. https://doi.org/10.3390/brainsci12040496
dc.identifier.doi10.3390/brainsci12040496
dc.identifier.orcidhttps://orcid.org/0000-0003-3228-6501
dc.identifier.orcidhttps://orcid.org/0000-0003-0907-8931
dc.identifier.orcidhttps://orcid.org/0000-0002-2563-4996
dc.identifier.urihttps://ir.ua.edu/handle/123456789/12297
dc.languageEnglish
dc.language.isoen_US
dc.publisherMDPI
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectconnectome
dc.subjectdementia
dc.subjecthippocampus
dc.subjectmagnetic resonance imaging
dc.subjectresting state
dc.subjectMILD COGNITIVE IMPAIRMENT
dc.subjectPROPENSITY SCORE METHODS
dc.subjectEARLY ALZHEIMERS-DISEASE
dc.subjectINDIVIDUAL-DIFFERENCES
dc.subjectFUNCTIONAL CONNECTIVITY
dc.subjectARTIFACT REMOVAL
dc.subjectAMYLOID BURDEN
dc.subjectHEALTHY-YOUNG
dc.subjectRISK
dc.subjectVARIABILITY
dc.subjectNeurosciences
dc.titleYoung Adults with a Parent with Dementia Show Early Abnormalities in Brain Activity and Brain Volume in the Hippocampus: A Matched Case-Control Studyen_US
dc.typeArticle
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