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Oxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problems

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dc.contributor.authorGlenn, Andrea L.
dc.contributor.authorLochman, John E.
dc.contributor.authorDishion, Thomas
dc.contributor.authorPowell, Nicole P.
dc.contributor.authorBoxmeyer, Caroline
dc.contributor.authorQu, Lixin
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherArizona State University
dc.contributor.otherArizona State University-Tempe
dc.date.accessioned2023-09-28T19:04:17Z
dc.date.available2023-09-28T19:04:17Z
dc.date.issued2018
dc.description.abstractCoping Power is an evidence-based preventive intervention program for youth with aggressive behavior problems that has traditionally been delivered in small group formats. Because of concerns about iatrogenic effects secondary to aggregation of high risk youth, the current study examined whether genetic risk may moderate intervention outcome when youth were randomly assigned to group versus individual formats of an intervention. The oxytocin receptor gene (OXTR) has been associated with social behavior and may influence susceptibility to social reinforcement in general and deviant peer influence in particular. One variant of OXTR (rs2268493) was examined in 197 fourth-grade African-American children (64% male) who were randomly assigned to Group Coping Power or Individual Coping Power (Lochman et al. 2015). Longitudinal assessments of teacher- and parent-reported behavior were collected through a 1-year follow-up. Growth curve analyses revealed a genotype by delivery format interaction. Youth with the A/A genotype demonstrated reductions in externalizing problems over the course of the intervention regardless of intervention format. In contrast, carriers of the G allele receiving the group-based intervention showed little improvement during the intervention and a worsening of symptoms during the follow-up year, while those receiving the individual format demonstrated reductions in externalizing problems. Given the associations between this OXTR variant and social bonding, carriers of the G allele may be more sensitive to social rewards from deviant peers in the group setting. This study suggests that genetic factors may be useful in predicting which type of intervention will be most effective for a particular individual.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationGlenn, A. L., Lochman, J. E., Dishion, T., Powell, N. P., Boxmeyer, C., & Qu, L. (2017). Oxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problems. In Prevention Science (Vol. 19, Issue 1, pp. 38–48). Springer Science and Business Media LLC. https://doi.org/10.1007/s11121-017-0777-1
dc.identifier.doi10.1007/s11121-017-0777-1
dc.identifier.urihttps://ir.ua.edu/handle/123456789/10784
dc.languageEnglish
dc.language.isoen_US
dc.publisherSpringer
dc.subjectAggression
dc.subjectConduct problems
dc.subjectOxytocin receptor gene
dc.subjectPreventive intervention
dc.subjectDeviant peer
dc.subjectCOPING POWER PROGRAM
dc.subjectAGGRESSIVE-CHILDREN
dc.subjectPEER CONTAGION
dc.subjectBEHAVIOR
dc.subjectPREVENTION
dc.subjectCHILDHOOD
dc.subjectCOMMUNITY
dc.subjectTRAITS
dc.subjectPublic, Environmental & Occupational Health
dc.titleOxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problemsen_US
dc.typeArticle
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