Highly Sensitive Readout Interface for Real-Time Differential Precision Measurements with Impedance Biosensors

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dc.contributor.authorNeshani, Sara
dc.contributor.authorMomeni, Kasra
dc.contributor.authorChen, Degang J.
dc.contributor.authorNeihart, Nathan M.
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherIowa State University
dc.date.accessioned2023-09-28T19:15:46Z
dc.date.available2023-09-28T19:15:46Z
dc.date.issued2023
dc.description.abstractField deployment is critical to developing numerous sensitive impedance transducers. Precise, cost-effective, and real-time readout units are being sought to interface these sensitive impedance transducers for various clinical or environmental applications. This paper presents a general readout method with a detailed design procedure for interfacing impedance transducers that generate small fractional changes in the impedance characteristics after detection. The emphasis of the design is obtaining a target response resolution considering the accuracy in real-time. An entire readout unit with amplification/filtering and real-time data acquisition and processing using a single microcontroller is proposed. Most important design parameters, such as the signal-to-noise ratio (SNR), common-mode-to-differential conversion, digitization configuration/speed, and the data processing method are discussed here. The studied process can be used as a general guideline to design custom readout units to interface with various developed transducers in the laboratory and verify the performance for field deployment and commercialization. A single frequency readout unit with a target 8-bit resolution to interface differentially placed transducers (e.g., bridge configuration) is designed and implemented. A single MCU is programmed for real-time data acquisition and sine fitting. The 8-bit resolution is achieved even at low SNR levels of roughly 7 dB by setting the component values and fitting algorithm parameters with the given methods.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationNeshani, S., Momeni, K., Chen, D. J., & Neihart, N. M. (2023). Highly Sensitive Readout Interface for Real-Time Differential Precision Measurements with Impedance Biosensors. In Biosensors (Vol. 13, Issue 1, p. 77). MDPI AG. https://doi.org/10.3390/bios13010077
dc.identifier.doi10.3390/bios13010077
dc.identifier.orcidhttps://orcid.org/0000-0002-4209-1129
dc.identifier.urihttps://ir.ua.edu/handle/123456789/11198
dc.languageEnglish
dc.language.isoen_US
dc.publisherMDPI
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectreal-time
dc.subjectimpedance biosensor
dc.subjectlow-cost
dc.subjectprecision
dc.subjectsensitive
dc.subjectreadout
dc.subjectinterface
dc.subjectSPECTROSCOPY
dc.subjectALGORITHM
dc.subjectAMPLITUDE
dc.subjectChemistry, Analytical
dc.subjectNanoscience & Nanotechnology
dc.subjectInstruments & Instrumentation
dc.titleHighly Sensitive Readout Interface for Real-Time Differential Precision Measurements with Impedance Biosensorsen_US
dc.typeArticle
dc.typetext

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