Considerations when choosing a genetic model organism for metabolomics studies

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dc.contributor.authorReed, Laura K.
dc.contributor.authorBaer, Charles F.
dc.contributor.authorEdison, Arthur S.
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherUniversity of Florida
dc.contributor.otherUniversity of Georgia
dc.date.accessioned2023-09-28T19:13:50Z
dc.date.available2023-09-28T19:13:50Z
dc.date.issued2017
dc.description.abstractModel organisms are important in many areas of chemical biology. In metabolomics, model organisms can provide excellent samples for methods development as well as the foundation of comparative phylometabolomics, which will become possible as metabolomics applications expand. Comparative studies of conserved and unique metabolic pathways will help in the annotation of metabolites as well as provide important new targets of investigation in biology and biomedicine. However, most chemical biologists are not familiar with genetics, which needs to be considered when choosing a model organism. In this review we summarize the strengths and weaknesses of several genetic systems, including natural isolates, recombinant inbred lines, and genetic mutations. We also discuss methods to detect targets of selection on the metabolome.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationReed, L. K., Baer, C. F., & Edison, A. S. (2017). Considerations when choosing a genetic model organism for metabolomics studies. In Current Opinion in Chemical Biology (Vol. 36, pp. 7–14). Elsevier BV. https://doi.org/10.1016/j.cbpa.2016.12.005
dc.identifier.doi10.1016/j.cbpa.2016.12.005
dc.identifier.orcidhttps://orcid.org/0000-0002-4381-494X
dc.identifier.orcidhttps://orcid.org/0000-0002-5686-2350
dc.identifier.urihttps://ir.ua.edu/handle/123456789/11102
dc.languageEnglish
dc.language.isoen_US
dc.publisherElsevier
dc.subjectGENOME-WIDE ASSOCIATION
dc.subjectSMALL-MOLECULE SIGNALS
dc.subjectCAENORHABDITIS-ELEGANS
dc.subjectDROSOPHILA-MELANOGASTER
dc.subjectREFERENCE PANEL
dc.subjectFUNCTIONAL GENOMICS
dc.subjectAEROBIC GLYCOLYSIS
dc.subjectCOMPLEX TRAITS
dc.subjectYEAST CROSS
dc.subjectC. ELEGANS
dc.subjectBiochemistry & Molecular Biology
dc.subjectBiophysics
dc.titleConsiderations when choosing a genetic model organism for metabolomics studiesen_US
dc.typeReview
dc.typetext
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