Host-associated microbiomes are predicted by immune system complexity and climate

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dc.contributor.authorWoodhams, Douglas C.
dc.contributor.authorBletz, Molly C.
dc.contributor.authorBecker, C. Guilherme
dc.contributor.authorBender, Hayden A.
dc.contributor.authorBuitrago-Rosas, Daniel
dc.contributor.authorDiebboll, Hannah
dc.contributor.authorHuynh, Roger
dc.contributor.authorKearns, Patrick J.
dc.contributor.authorKueneman, Jordan
dc.contributor.authorKurosawa, Emmi
dc.contributor.authorLaBumbard, Brandon C.
dc.contributor.authorLyons, Casandra
dc.contributor.authorMcNally, Kerry
dc.contributor.authorSchliep, Klaus
dc.contributor.authorShankar, Nachiket
dc.contributor.authorTokash-Peters, Amanda G.
dc.contributor.authorVences, Miguel
dc.contributor.authorWhetstone, Ross
dc.contributor.otherUniversity of Massachusetts Boston
dc.contributor.otherSmithsonian Institution
dc.contributor.otherSmithsonian Tropical Research Institute
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherUniversity of Rwanda
dc.contributor.otherBraunschweig University of Technology
dc.date.accessioned2023-09-28T19:11:42Z
dc.date.available2023-09-28T19:11:42Z
dc.date.issued2020
dc.description.abstractBackground Host-associated microbiomes, the microorganisms occurring inside and on host surfaces, influence evolutionary, immunological, and ecological processes. Interactions between host and microbiome affect metabolism and contribute to host adaptation to changing environments. Meta-analyses of host-associated bacterial communities have the potential to elucidate global-scale patterns of microbial community structure and function. It is possible that host surface-associated (external) microbiomes respond more strongly to variations in environmental factors, whereas internal microbiomes are more tightly linked to host factors. Results Here, we use the dataset from the Earth Microbiome Project and accumulate data from 50 additional studies totaling 654 host species and over 15,000 samples to examine global-scale patterns of bacterial diversity and function. We analyze microbiomes from non-captive hosts sampled from natural habitats and find patterns with bioclimate and geophysical factors, as well as land use, host phylogeny, and trophic level/diet. Specifically, external microbiomes are best explained by variations in mean daily temperature range and precipitation seasonality. In contrast, internal microbiomes are best explained by host factors such as phylogeny/immune complexity and trophic level/diet, plus climate. Conclusions Internal microbiomes are predominantly associated with top-down effects, while climatic factors are stronger determinants of microbiomes on host external surfaces. Host immunity may act on microbiome diversity through top-down regulation analogous to predators in non-microbial ecosystems. Noting gaps in geographic and host sampling, this combined dataset represents a global baseline available for interrogation by future microbial ecology studies.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationWoodhams, D. C., Bletz, M. C., Becker, C. G., Bender, H. A., Buitrago-Rosas, D., Diebboll, H., Huynh, R., Kearns, P. J., Kueneman, J., Kurosawa, E., LaBumbard, B. C., Lyons, C., McNally, K., Schliep, K., Shankar, N., Tokash-Peters, A. G., Vences, M., & Whetstone, R. (2020). Host-associated microbiomes are predicted by immune system complexity and climate. In Genome Biology (Vol. 21, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s13059-019-1908-8
dc.identifier.doi10.1186/s13059-019-1908-8
dc.identifier.orcidhttps://orcid.org/0000-0003-2941-0161
dc.identifier.orcidhttps://orcid.org/0000-0003-4120-9356
dc.identifier.orcidhttps://orcid.org/0000-0003-2941-0161
dc.identifier.orcidhttps://orcid.org/0000-0001-9182-8388
dc.identifier.orcidhttps://orcid.org/0000-0002-6900-0311
dc.identifier.orcidhttps://orcid.org/0000-0002-2520-2464
dc.identifier.orcidhttps://orcid.org/0000-0002-9274-6218
dc.identifier.orcidhttps://orcid.org/0000-0003-0747-0817
dc.identifier.orcidhttps://orcid.org/0000-0003-4559-1046
dc.identifier.urihttps://ir.ua.edu/handle/123456789/11021
dc.languageEnglish
dc.language.isoen_US
dc.publisherBMC
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiodiversity
dc.subjectGut microbiome
dc.subjectMicrobial ecology
dc.subjectSkin microbiome
dc.subjectSymbiosis
dc.subjectWolbachia
dc.subjectGUT MICROBIOTA
dc.subjectBACTERIAL COMMUNITIES
dc.subjectECOLOGICAL FACTORS
dc.subjectGLOBAL PATTERNS
dc.subjectWOLBACHIA
dc.subjectDIVERSITY
dc.subjectEVOLUTION
dc.subjectDENGUE
dc.subjectLIFE
dc.subjectSALAMANDER
dc.subjectBiotechnology & Applied Microbiology
dc.subjectGenetics & Heredity
dc.titleHost-associated microbiomes are predicted by immune system complexity and climateen_US
dc.typeArticle
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