Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson's Disease

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dc.contributor.authorGaeta, Anthony L.
dc.contributor.authorCaldwell, Kim A.
dc.contributor.authorCaldwell, Guy A.
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.contributor.otherUniversity of Alabama Birmingham
dc.date.accessioned2023-09-28T22:03:53Z
dc.date.available2023-09-28T22:03:53Z
dc.date.issued2019
dc.description.abstractParkinson's Disease (PD) is the second-most common neurodegenerative disease in the world, yet the fundamental and underlying causes of the disease are largely unknown, and treatments remain sparse and impotent. Several biological systems have been employed to model the disease but the nematode roundworm Caenorhabditis elegans (C. elegans) shows unique promise among these to disinter the elusive factors that may prevent, halt, and/or reverse PD phenotypes. Some of the most salient of these C. elegans models of PD are those that position the misfolding-prone protein alpha-synuclein (-syn), a hallmark pathological component of PD, as the primary target for scientific interrogation. By transgenic expression of human -syn in different tissues, including dopamine neurons and muscle cells, the primary cellular phenotypes of PD in humans have been recapitulated in these C. elegans models and have already uncovered multifarious genetic factors and chemical compounds that attenuate dopaminergic neurodegeneration. This review describes the paramount discoveries obtained through the application of different -syn models of PD in C. elegans and highlights their established utility and respective promise to successfully uncover new conserved genetic modifiers, functional mechanisms, therapeutic targets and molecular leads for PD with the potential to translate to humans.en_US
dc.format.mediumelectronic
dc.format.mimetypeapplication/pdf
dc.identifier.citationGaeta, A., Caldwell, K., & Caldwell, G. (2019). Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s Disease. In Brain Sciences (Vol. 9, Issue 4, p. 73). MDPI AG. https://doi.org/10.3390/brainsci9040073
dc.identifier.doi10.3390/brainsci9040073
dc.identifier.orcidhttps://orcid.org/0000-0002-8283-9090
dc.identifier.orcidhttps://orcid.org/0000-0003-1580-6122
dc.identifier.orcidhttps://orcid.org/0000-0003-2959-7990
dc.identifier.urihttps://ir.ua.edu/handle/123456789/12229
dc.languageEnglish
dc.language.isoen_US
dc.publisherMDPI
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectalpha-synuclein
dc.subjectParkinson
dc.subjectC
dc.subjectelegans
dc.subjectneurodegeneration
dc.subjectdopamine
dc.subjectCAENORHABDITIS-ELEGANS
dc.subjectDOPAMINERGIC NEURODEGENERATION
dc.subjectLEWY BODIES
dc.subjectIDENTIFICATION
dc.subjectHUNTINGTIN
dc.subjectMUTATIONS
dc.subjectOLIGOMERS
dc.subjectGERMLINE
dc.subjectTOXICITY
dc.subjectNETWORK
dc.subjectNeurosciences
dc.titleFound in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson's Diseaseen_US
dc.typeReview
dc.typetext
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