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Increased Volume of the Striatum in Psychopathic Individuals

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dc.contributor.authorGlenn, Andrea L.
dc.contributor.authorRaine, Adrian
dc.contributor.authorYaralian, Pauline S.
dc.contributor.authorYang, Yaling
dc.contributor.otherUniversity of Pennsylvania
dc.contributor.otherUniversity of California System
dc.contributor.otherUniversity of California Los Angeles
dc.contributor.otherUniversity of Alabama Tuscaloosa
dc.date.accessioned2021-06-09T15:24:39Z
dc.date.available2021-06-09T15:24:39Z
dc.date.issued2010
dc.description.abstractBackground: The corpus striatum, comprised of the caudate, putamen, and globus pallidus, plays an important role in reward processing and may be involved in the pathophysiology of antisocial behavior. Few studies have explored whether differences are present in the striatum of antisocial individuals. Here, we examine the structure of the striatum in relation to psychopathy. Methods: Using a case-control design, we examined the volume of the striatum in psychopathic individuals compared with control subjects matched for age, sex, ethnicity, and substance dependence. Twenty-two psychopathic individuals assessed using the Psychopathy Checklist-Revised and 22 comparison subjects underwent structural magnetic resonance imaging. Volumes of the left and right lenticular nucleus (putamen and globus pallidus), caudate head, and caudate body were assessed and the psychopathic and control groups were compared. Results: Psychopathic individuals showed a 9.6% increase in striatum volumes. Analyses of subfactors of psychopathy revealed that caudate body volumes were primarily associated with the interpersonal and affective features of psychopathy, while caudate head volumes were primarily associated with the impulsive, stimulation-seeking features. Conclusions: These findings provide new evidence for differences in the striatum of psychopathic individuals. This structural difference may partially underlie the reward-seeking and decision-making deficits associated with psychopathy.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.citationGlenn, A., Raine, A., Yaralian, P., Yang, Y. (2010): Increased Volume of the Striatum in Psychopathic Individuals. Biological Psychiatry, 67(1).
dc.identifier.doi10.1016/j.biopsych.2009.06.018
dc.identifier.urihttp://ir.ua.edu/handle/123456789/7771
dc.languageEnglish
dc.language.isoen_US
dc.publisherElsevier
dc.subjectAntisocial
dc.subjectimaging
dc.subjectpsychopathy
dc.subjectreward
dc.subjectstriatum
dc.subjectstructural MRI
dc.subjectVENTROMEDIAL PREFRONTAL CORTEX
dc.subjectCRIMINAL PSYCHOPATHS
dc.subjectSCHIZOPHRENIA
dc.subjectREWARD
dc.subjectBRAIN
dc.subjectABNORMALITIES
dc.subjectRESPONSES
dc.subjectMORALITY
dc.subjectAMYGDALA
dc.subjectVIOLENCE
dc.subjectNeurosciences
dc.subjectPsychiatry
dc.subjectNeurosciences & Neurology
dc.subject.lcshCorpus striatum
dc.subject.lcshPsychology, Pathological
dc.subject.lcshAntisocial personality disorders
dc.titleIncreased Volume of the Striatum in Psychopathic Individualsen_US
dc.typetext
dc.typeArticle

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