The present study sought to analyze the moderating effects of resistance to persuasion upon the relationship between individualism/collectivism, uncertainty avoidance, political ideology, traditional and social media perception, and social media usage and COVID-19 prevention measures on both the attitudinal and behavioral dimension. To accomplish this, a survey questionnaire was administered via Amazon mTurk, a service that connects survey respondents to relevant surveys in exchange for compensation. This recruitment method was chosen because it produced a more representative sample that recruiting from the university. Data was analyzed using multiple regression analysis in SPSS with resistance to persuasion as the moderating variable. The results showed that COVID-19 prevention attitudes were significantly related to collectivism, uncertainty avoidance, political ideology, traditional and social media perception, and social media usage. COVID-19 prevention behavior was significantly related to collectivism, uncertainty avoidance, political ideology, and traditional media perception. The results also showed that resistance to persuasion alone does not have a significant effect on COVID-19 prevention compliance, but that it is a significant moderating variable in the relationship between COVID-19 attitudes and collectivism, COVID-19 prevention attitudes and behavior and political ideology, COVID-19 behavior and traditional media perception, COVID-19 prevention attitudes and social media perception, and COVID-19 prevention attitudes and behavior and times checking social media.