Introduction/Purpose: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. The purpose of this quality improvement project program evaluation was to determine effectiveness 6 months after program implementation of a new practice protocol to increase HPV vaccination rates to children and adolescent’s 9 to 13 years of age. Methods: Educational sessions on practice protocol and strategies for reducing barriers to vaccination were held weekly for providers and staff prior to implementation. The vaccine was recommended by saying “Your child is due the HPV cancer vaccine. We’ll give this vaccine at the end of today’s visit.” Adherence to the new practice protocol and HPV vaccination rates were evaluated on a weekly basis through chart audits. The CDC Framework for Program Evaluation sought to determine the effectiveness of this program six months after full implementation. Descriptive statistics and a Chi Square analysis were used to analyze the pre and post data on HPV vaccination rates. Results: HPV vaccination rate was calculated using the percentage of patients that received the HPV vaccine before and after the intervention. The pre-intervention rates and post-intervention rates were compared through a Chi Square analysis. Patients that were already vaccinated were included as they represented successful vaccination rates. The program was implemented July 2021 thru September 2021. During this time, HPV vaccination rates did increase significantly (p=<0.00001). This program evaluation was reevaluated six months after program implementation of the new practice protocol to determine effectiveness. Immediately pre-implementation, 41% of patients presenting were vaccinated. Immediately post-implementation, 70% were vaccinated, X2(1, n=329)=21,1076, p=<0.00001. Six months post-implementation, 64% were vaccinated. X2(1,n=146)=7.3587, p=.006674. Discussion: Provider education and improved office protocols regarding HPV vaccination improved vaccinations rates in the pediatric practice. According to the CDC, provider recommendation can be the biggest influence in a parent’s decision to get HPV vaccine for their child and adding the word “cancer” is thought to remind parents that this is not a vaccine associated with sexual activity, but it is a vaccine to prevent cancer. Although still improved over baseline, waning improvement six months after implementation stresses the need for continual reinforcement.