Reversible Dimerization of Human Serum Albumin

Show simple item record

dc.contributor.author Chubarov, Alexey
dc.contributor.author Spitsyna, Anna
dc.contributor.author Krumkacheva, Olesya
dc.contributor.author Mitin, Dmitry
dc.contributor.author Suvorov, Daniil
dc.contributor.author Tormyshev, Victor
dc.contributor.author Fedin, Matvey
dc.contributor.author Bowman, Michael K.
dc.contributor.author Bagryanskaya, Elena
dc.date.accessioned 2021-08-25T21:04:16Z
dc.date.available 2021-08-25T21:04:16Z
dc.date.issued 2020
dc.identifier.citation Chubarov, A., Spitsyna, A., Krumkacheva, O., Mitin, D., Suvorov, D., Tormyshev, V., Fedin, M., Bowman, M., Bagryanskaya, E. (2020): Reversible Dimerization of Human Serum Albumin. Molecules. 26(1). en_US
dc.identifier.uri http://ir.ua.edu/handle/123456789/8069
dc.description.abstract Pulsed Dipolar Spectroscopy (PDS) methods of Electron Paramagnetic Resonance (EPR) were used to detect and characterize reversible non-covalent dimers of Human Serum Albumin (HSA), the most abundant protein in human plasma. The spin labels, MTSL and OX063, were attached to Cys-34 and these chemical modifications of Cys-34 did affect the dimerization of HSA, indicating that other post-translational modifications can modulate dimer formation. At physiologically relevant concentrations, HSA does form weak, non-covalent dimers with a well-defined structure. Dimer formation is readily reversible into monomers. Dimerization is very relevant to the role of HSA in the transport, binding, and other physiological processes. en_US
dc.description.uri https://doi.org/10.3390/molecules26010108
dc.format.mimetype application/pdf
dc.language English en_US
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject human serum albumin en_US
dc.subject pulse dipole EPR en_US
dc.subject aggregation en_US
dc.title Reversible Dimerization of Human Serum Albumin en_US
dc.type text


Files in this item

This item appears in the following Collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0/ Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/

Search DSpace


Browse

My Account