Photopolymerization-based synthesis of iron oxide nanoparticle embedded PNIPAM nanogels for biomedical applications

Show simple item record Denmark, Daniel J. Hyde, Robert H. Gladney, Charlotte Manh-Huong Phan Bisht, Kirpal S. Srikanth, Hariharan Mukherjee, Pritish Witanachchi, Sarath
dc.contributor.other State University System of Florida
dc.contributor.other University of South Florida
dc.contributor.other University of Alabama Tuscaloosa 2021-07-28T16:20:18Z 2021-07-28T16:20:18Z 2017
dc.identifier.citation Denmark, D., Hyde, R., Gladney, C., Phan, M., Bisht, K., Srikanth, H., Mukherjee, P., Witanachchi, S. (2017): Photopolymerization-Based Synthesis of Iron Oxide Nanoparticle Embedded PNIPAM Nanogels for Biomedical Applications. Drug Delivery. 24(1).
dc.description.abstract Conventional therapeutic techniques treat patients by delivering biotherapeutics to the entire body. With targeted delivery, biotherapeutics are transported to the afflicted tissue reducing exposure to healthy tissue. Targeted delivery devices are minimally composed of a stimuli responsive polymer allowing triggered release and magnetic nanoparticles enabling targeting as well as alternating magnetic field (AMF) heating. Although more traditional methods, like emulsion polymerization, have been used to realize such devices, the synthesis is problematic. For example, surfactants preventing agglomeration must be removed from the product increasing time and cost. Ultraviolet (UV) photopolymerization is more efficient and ensures safety by using biocompatible substances. Reactants selected for nanogel fabrication were N-isopropylacrylamide (monomer), methylene bis-acrylamide (crosslinker), and Irgacure 2959 (photoinitiator). The 10 nm superparamagnetic nanoparticles for encapsulation were composed of iron oxide. Herein, a low-cost, scalable, and rapid, custom-built UV photoreactor with in situ, spectroscopic monitoring system is used to observe synthesis. This method also allows in situ encapsulation of the magnetic nanoparticles simplifying the process. Nanogel characterization, performed by transmission electron microscopy, reveals size-tunable nanogel spheres between 40 and 800 nm in diameter. Samples of nanogels encapsulating magnetic nanoparticles were subjected to an AMF and temperature increase was observed indicating triggered release is possible. Results presented here will have a wide range of applications in medical sciences like oncology, gene delivery, cardiology, and endocrinology. en_US
dc.format.mimetype application/pdf
dc.language English
dc.language.iso en_US
dc.publisher Taylor & Francis
dc.subject Magnetic nanoparticles
dc.subject stimuli-responsive polymer
dc.subject targeted biotherapeutic delivery
dc.subject induction heating
dc.subject photopolymerization
dc.subject PARTICLES
dc.subject TURBIDITY
dc.subject DELIVERY
dc.subject Pharmacology & Pharmacy
dc.title Photopolymerization-based synthesis of iron oxide nanoparticle embedded PNIPAM nanogels for biomedical applications en_US
dc.type text
dc.type Article
dc.identifier.doi 10.1080/10717544.2017.1373164

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