Increased Volume of the Striatum in Psychopathic Individuals

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dc.contributor.author Glenn, Andrea
dc.contributor.author Raine, Adrian
dc.contributor.author Yaralian, Pauline S.
dc.contributor.author Yang, Yaling
dc.date.accessioned 2021-06-09T15:24:39Z
dc.date.available 2021-06-09T15:24:39Z
dc.date.issued 2010
dc.identifier.citation Glenn, A., Raine, A., Yaralian, P., Yang, Y. (2010): Increased Volume of the Striatum in Psychopathic Individuals. Biological Psychiatry, 67(1). en_US
dc.identifier.uri http://ir.ua.edu/handle/123456789/7771
dc.description.abstract Background: The corpus striatum, comprised of the caudate, putamen, and globus pallidus, plays an important role in reward processing and may be involved in the pathophysiology of antisocial behavior. Few studies have explored whether differences are present in the striatum of antisocial individuals. Here we examine the structure of the striatum in relation to psychopathy. Methods: Using a case-control design, we examined the volume of the striatum in psychopathic individuals compared to controls matched for age, sex, ethnicity, and substance dependence. Twenty-two psychopathic individuals assessed using the Psychopathy Checklist – Revised and twenty-two comparison subjects underwent structural magnetic resonance imaging (MRI). Volumes of the left and right lenticular nucleus (putamen and globus pallidus), caudate head, and caudate body were assessed and the psychopathic and control groups were compared. Results: Psychopathic individuals showed a 9.6% increase in striatum volumes. Analyses of subfactors of psychopathy revealed that caudate body volumes were primarily associated with the interpersonal and affective features of psychopathy, while caudate head volumes were primarily associated with the impulsive, stimulation-seeking features. Conclusions: These findings provide new evidence for differences in the striatum of psychopathic individuals. This structural difference may partially underlie the reward-seeking and decision-making deficits associated with psychopathy. en_US
dc.description.uri https://doi.org/10.1016/j.biopsych.2009.06.018
dc.format.mimetype application/pdf
dc.language English en_US
dc.subject.lcsh Corpus striatum en_US
dc.subject.lcsh Psychology, Pathological en_US
dc.subject.lcsh Antisocial personality disorders en_US
dc.title Increased Volume of the Striatum in Psychopathic Individuals en_US
dc.type text


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