Investigation of biodegradable zn-li-cu alloys for cardiovascular stent applications

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dc.contributor Weaver, Mark L.
dc.contributor Kumar, Nilesh
dc.contributor Fonseca, Daniel J.
dc.contributor Thomas, Vinoy
dc.contributor.advisor Reddy, Ramana G. Young, Jacob Steele 2021-05-12T16:28:08Z 2021-05-12T16:28:08Z 2020-12
dc.identifier.other u0015_0000001_0003685
dc.identifier.other Young_alatus_0004D_14368
dc.description Electronic Thesis or Dissertation
dc.description.abstract Zinc has been recently proposed as a suitable biodegradable material for temporary medical device applications due to an intermediate corrosion rate, high biocompatibility, and ease of processing. While pure zinc fails to meet the minimum mechanical property requirements for cardiovascular stents, Zn can be easily customized through alloying with non-toxic elements to improve both its strength and ductility while maintaining an ideal degradation behavior and biocompatibility.In this research project, the novel Zn-Li-Cu alloy system has been investigated and developed to optimize the mechanical properties and corrosion behavior for cardiovascular stent applications through simulation and in vitro examination. Through this research work, the primary accomplishments were: • Synthesized Zn-Li-Cu alloy ingots and sheets through an inert atmosphere casting, annealing, and hot rolling procedure. Individual samples are sectioned, ground, and polished for characterization and corrosion testing. • Characterized the morphology and chemistry of rolled alloys through optical microscopy, SEM, XRD, EDS, ICP-OES, FTIR, and XPS. Experimental and nominal chemistries are compared through thermodynamic modeling of the Zn-Li-Cu phase diagram with PANDAT software. • Simulated the biodegradation behavior in the human body through in vitro immersion testing and EIS using HBSS to examine weight loss-based corrosion rate, corrosion products and their effect on corrosion resistance, and long-term structural stability. • Determined the ultimate tensile strength, yield strength, elongation to failure, modulus of elongation, and Vickers hardness of rolled alloys. Tensile fracture surfaces were analyzed to find relationships between mechanical properties, fracture behavior, and alloying element concentration. • Measured the cell viability and relative metabolic behavior of NIH3T3 fibroblast cells on Zn alloy substrates through indirect MTS cytotoxicity testing to ascertain potential toxicity effects. • Established the optimal alloy chemistry to best meet the design criteria for cardiovascular stent devices and ascertain avenues for future property improvements and optimization.
dc.format.extent 150 p.
dc.format.medium electronic
dc.format.mimetype application/pdf
dc.language English
dc.language.iso en_US
dc.publisher University of Alabama Libraries
dc.relation.ispartof The University of Alabama Electronic Theses and Dissertations
dc.relation.ispartof The University of Alabama Libraries Digital Collections
dc.relation.hasversion born digital
dc.rights All rights reserved by the author unless otherwise indicated.
dc.subject.other Materials Science
dc.title Investigation of biodegradable zn-li-cu alloys for cardiovascular stent applications
dc.type thesis
dc.type text University of Alabama. Department of Metallurgical and Materials Engineering Metallurgical/Materials Engineering The University of Alabama doctoral Ph.D.

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