The minimal renormalizable supersymmetric SO(10) model, an SO(10) framework with only one 10 and one 1̅2̅6̅ Higgs multiplets in the Yukawa sector, is attractive because of its high predictive power for the neutrino oscillation data. However, this model suffers from problems related to running of gauge couplings. The gauge coupling unification may be spoiled due to the presence of Higgs multiplets much lighter than the grand unification (GUT) scale. In addition, the gauge couplings blow up around the GUT scale because of the presence of Higgs multiplets of large representations. We consider the minimal SO(10) model in the warped extra dimension and find a possibility to solve these problems.