The Higgs boson production by the gluon fusion and its decay into two photons at the LHC are investigated in the context of the gauge-Higgs unification scenario. The qualitative behaviors for these processes in the gauge-Higgs unification are quite distinguishable from those of the standard model and the universal extra dimension scenario because of the overall sign difference for the effective couplings induced by one-loop corrections through the Kaluza-Klein modes. For the Kaluza-Klein mode mass smaller than 1 TeV, the Higgs production cross section and its branching ratio into two photons are sizably deviated from those in the standard model. Associated with the discovery of the Higgs boson, this deviation may be measured at the LHC.