A simple supersymmetric SO(10) grand unified theory (GUT) in five dimensions is considered. The fifth dimension is compactified on the S¹/(Z₂ × Z₂') orbifold possessing two inequivalent fixed points. In our setup, all matter and Higgs multiplets reside on one brane (PS brane) where the original SO(10) gauge group is broken down to the Pati-Salam (PS) gauge group, SU(4)⌄c × SU(2)⌄L × SU(2)⌄R, by the orbifold boundary condition, while only the SO(10) gauge multiplet resides in the bulk. The further breaking of the PS symmetry to the standard model gauge group is realized by Higgs multiplets on the PS brane as usual in four-dimensional models. Proton decay is fully suppressed. In our simple setup, the gauge coupling unification is realized after incorporating threshold corrections of Kaluza-Klein modes. When supersymmetry is assumed to be broken on the other brane, supersymmetry breaking is transmitted to the PS brane through the gaugino mediation with the bulk gauge multiplet.