Simple supersymmetric SO(10) grand unified theory in five dimensions is proposed, in which the fifth dimension is compactified on the S¹/(Z₂ × Z₂′) orbifold with two inequivalent branes at the orbifold fixed points. In this model, all matter and Higgs multiplets reside on one brane (PS brane) where the Pati-Salam (PS) symmetry is manifest, while only the SO(10) gauge multiplet resides on the bulk. The supersymmetry breaking on the other brane [SO(10) brane] is transmitted to the PS brane through the gaugino mediation with the bulk gauge multiplet. We examine sparticle mass spectrum in this setup and show that the neutralino LSP as the dark matter candidate can be realized when the compactification scale of the fifth dimension is higher than the PS symmetry breaking scale, keeping the successful gauge coupling unification after incorporating threshold corrections of Kaluza-Klein modes of the bulk gauge multiplets.