In the context of the gauge-Higgs unification scenario in a 5-dimensional flat spacetime, we investigate Higgs boson production via gluon fusion and its diphoton decay mode at the LHC. We show that the signal strength of the Higgs diphoton decay mode observed at ATLAS and CMS, which is considerably larger than the Standard Model expectation, can be explained by a simple gauge-Higgs unification model with color-singlet bulk fermions to which a half-periodic boundary condition is assigned. The bulk fermions also play a crucial role in reproducing the observed Higgs boson mass around 125 GeV.