• Patterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorder 

  Channell, Marie Moore; Phillips, B. Allyson; Loveall, Susan J.; Conners, Frances A.; Bussanich, Paige M.; Klinger, Laura Grofer (BMC, 2015)

  Background: Prevalence estimates of autism spectrum disorder (ASD) in Down syndrome (DS) are highly varied. This variation is partly due to the difficulty of screening for and diagnosing comorbid ASD in individuals with a ...
• Drosophila Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution 

  Participating Students Fac Genomic (Oxford University Press, 2015)

  The Muller F element (4.2 Mb, similar to 80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact ...
• Using linkage maps to correct and scaffold de novo genome assemblies: methods, challenges, and computational tools 

  Fierst, Janna L. (Frontiers, 2015)

  Modern high-throughput DNA sequencing has made it possible to inexpensively produce genome sequences, but in practice many of these draft genomes are fragmented and incomplete. Genetic linkage maps based on recombination ...
• Metabolomic and Gene Expression Profiles Exhibit Modular Genetic and Dietary Structure Linking Metabolic Syndrome Phenotypes in Drosophila 

  Williams, Stephanie; Dew-Budd, Kelly; Davis, Kristen; Anderson, Julie; Bishop, Ruth; Freeman, Kenda; Davis, Dana; Bray, Katherine; Perkins, Lauren; Hubickey, Joana; Reed, Laura K. (Genetics Society of America, 2015)

  Genetic and environmental factors influence complex disease in humans, such as metabolic syndrome, and Drosophila melanogaster serves as an excellent model in which to test these factors experimentally. Here we explore the ...
• Retrotransposons Are the Major Contributors to the Expansion of the Drosophila ananassae Muller F Element 

  Participating Students Fac (Oxford University Press, 2017)

  The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (similar to 5.2 Mb) is the smallest chromosome in Drosophila melanogaster, ...
• Dopamine induces soluble alpha-synuclein oligomers and nigrostriatal degeneration 

  Mor, Danielle E.; Tsika, Elpida; Mazzulli, Joseph R.; Gould, Neal S.; Kim, Hanna; Daniels, Malcolm J.; Doshi, Shachee; Gupta, Preetika; Grossman, Jennifer L.; Tan, Victor X.; Kalb, Robert G.; Caldwell, Kim A.; Caldwell, Guy A.; Wolfe, John H.; Ischiropoulos, Harry (Nature Portfolio, 2017)

  Parkinson's disease (PD) is defined by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy body inclusions containing aggregated alpha-synuclein. Efforts to explain dopamine neuron vulnerability ...
• The Prevalence and Severity of Tooth Wear in Type 2 Diabetic Patients 

  Srisilapanan, Patcharawan; Jindarat, Matee; Roseman, Jeffrey (Hindawi, 2018)

  Objective. To assess the prevalence and severity of tooth wear in type 2 diabetic patients. Methods. Attendees at a diabetic clinic at Wiang Pa Pao Hospital in Chiang Rai province, Thailand, were invited to take part in ...
• TLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice 

  Piao, Yibo; Gwon, Do Hyeong; Kang, Dong-Wook; Hwang, Tae Woong; Shin, Nara; Kwon, Hyeok Hee; Shin, Hyo Jung; Yin, Yuhua; Kim, Jwa-Jin; Hong, Jinpyo; Kim, Hyun-Woo; Kim, Yonghyun; Kim, Sang Ryong; Oh, Sang-Ha; Kim, Dong Woon (Biomed Central, 2018)

  Neuropathic pain is a complex, chronic pain state characterized by hyperalgesia, allodynia, and spontaneous pain. Accumulating evidence has indicated that the microglial Toll-like receptor 4 (TLR4) and autophagy are ...
• The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against alpha-Synuclein-Induced Toxicity (vol 55, pg 7533, 2018) 

  Kim, Hanna; Calatayud, Carles; Guha, Sanjib; Fernandez-Carasa, Irene; Berkowitz, Laura; Carballo-Carbajal, Iria; Ezquerra, Mario; Fernandez-Santiago, Ruben; Kapahi, Pankaj; Raya, Angel; Miranda-Vizuete, Antonio; Miguel Lizcano, Jose; Vila, Miquel; Caldwell, Kim A.; Caldwell, Guy A.; Consiglio, Antonella; Dalfo, Esther (Springer, 2018)

  With the author(s)' decision to opt for Open Choice the copyright of the article changed on March 2018 to A (c) The Author(s) 2018 and the name of one of the author was changed to "Sanjib Guha".
• The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against alpha-Synuclein-Induced Toxicity 

  Kim, Hanna; Calatayud, Caries; Guha, Sanjib; Fernandez-Carasa, Irene; Berkowitz, Laura; Carballo-Carbajal, Iria; Ezquerra, Mario; Fernandez-Santiago, Ruben; Kapahi, Pankaj; Raya, Angel; Miranda-Vizuete, Antonio; Miguel Lizcano, Jose; Vila, Miquel; Caldwell, Kim A.; Caldwell, Guy A.; Consiglio, Antonella; Dalfo, Esther (Springer, 2018)

  Parkinson's disease is associated with intracellular alpha-synuclein accumulation and ventral midbrain dopaminergic neuronal death in the Substantia Nigra of brain patients. The Rho GTPase pathway, mainly linking surface ...
• A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in Adult Drosophila 

  Loewen, Carin; Boekhoff-Falk, Grace; Ganetzky, Barry; Chtarbanova, Stanislava (Genetics Society of America, 2018)

  A screen for neuroprotective genes in Drosophila melanogaster led to the identification of a mutation that causes extreme, progressive loss of adult brain neuropil in conjunction with massive brain overgrowth. We mapped ...
• Age-dependent impairment of disease tolerance is associated with a robust transcriptional response following RNA virus infection in Drosophila 

  Sheffield, Lakbira; Sciambra, Noah; Evans, Alysa; Hagedorn, Eli; Goltz, Casey; Delfeld, Megan; Kuhns, Haley; Fierst, Janna L.; Chtarbanova, Stanislava (Oxford University Press, 2021)

  Advanced age in humans is associated with greater susceptibility to and higher mortality rates from infections, including infections with some RNA viruses. The underlying innate immune mechanisms, which represent the first ...
• Everyday Memory in People with Down Syndrome 

  Yang, Yingying; Himmelberger, Zachary M.; Robinson, Trent; Davis, Megan; Conners, Frances; Merrill, Edward (MDPI, 2021)

  Although memory functions in people with Down Syndrome (DS) have been studied extensively, how well people with DS remember things about everyday life is not well understood. In the current study, 31 adolescents/young ...
• Chromosome-Scale Genome for a Red-Fruited, Perpetual Flowering and Runnerless Woodland Strawberry (Fragaria vesca) 

  Alger, Elizabeth I.; Platts, Adrian E.; Deb, Sontosh K.; Luo, Xi; Ou, Shujun; Cao, Yao; Hummer, Kim E.; Xiong, Zhiyong; Knapp, Steven J.; Liu, Zhongchi; McKain, Michael R.; Edger, Patrick P. (Frontiers, 2021)
• Mindful Coping Power: Comparative Effects on Children's Reactive Aggression and Self-Regulation 

  Boxmeyer, Caroline L.; Miller, Shari; Romero, Devon E.; Powell, Nicole P.; Jones, Shannon; Qu, Lixin; Tueller, Stephen; Lochman, John E. (MDPI, 2021)

  Coping Power (CP) is an evidence-based preventive intervention for youth with disruptive behavior problems. This study examined whether Mindful Coping Power (MCP), a novel adaptation which integrates mindfulness into CP, ...
• Mass quarantine and mental health during COVID-19: A meta-analysis 

  Jin, Yuchang; Sun, Tengwei; Zheng, Peixuan; An, Junxiu (Elsevier, 2021)

  To reveal the complex relationships between quarantine and mental health during COVID-19, a meta-analysis was conducted involving 34 articles and a total sample size of 134,061. As the relationship between quarantine and ...
• Motor Preparation and Execution for Performance Difficulty: Centroparietal Beta Activation during the Effort Expenditure for Rewards Task as a Function of Motivation 

  Wilhelm, Ricardo A.; Threadgill, A. Hunter; Gable, Philip A. (MDPI, 2021)

  Debate exists as to the effects of anxiety in performance-based studies. However, no studies have examined the influence of motivation both in preparation of a motor movement and during movement performance. The present ...
• FARCI: Fast and Robust Connectome Inference 

  Meamardoost, Saber; Bhattacharya, Mahasweta; Hwang, Eun Jung; Komiyama, Takaki; Mewes, Claudia; Wang, Linbing; Zhang, Ying; Gunawan, Rudiyanto (MDPI, 2021)

  The inference of neuronal connectome from large-scale neuronal activity recordings, such as two-photon Calcium imaging, represents an active area of research in computational neuroscience. In this work, we developed FARCI ...
• Young Adults with a Parent with Dementia Show Early Abnormalities in Brain Activity and Brain Volume in the Hippocampus: A Matched Case-Control Study 

  McDonough, Ian M.; Mayhugh, Christopher; Moore, Mary Katherine; Brasfield, Mikenzi B.; Letang, Sarah K.; Madan, Christopher R.; Allen, Rebecca S. (MDPI, 2022)

  Having a parent with Alzheimer's disease (AD) and related dementias confers a risk for developing these types of neurocognitive disorders in old age, but the mechanisms underlying this risk are understudied. Although the ...
• Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy 

  Fanning, Saranna; Cirka, Haley; Thies, Jennifer L.; Jeong, Jooyoung; Niemi, Sarah M.; Yoon, Joon; Ho, Gary P. H.; Pacheco, Julian A.; Dettmer, Ulf; Liu, Lei; Clish, Clary B.; Hodgetts, Kevin J.; Hutchinson, John N.; Muratore, Christina R.; Caldwell, Guy A.; Caldwell, Kim A.; Selkoe, Dennis (Nature Portfolio, 2022)

  Synucleinopathy (Parkinson's disease (PD); Lewy body dementia) disease-modifying treatments represent a huge unmet medical need. Although the PD-causing protein alpha-synuclein (alpha S) interacts with lipids and fatty ...

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