Health disparities are differences that limit opportunities to attain optimal health. For many health conditions, minorities are living with or dying from the burden of disease, injury, and disability at early ages. Experts recommend physical activity, abstaining or quitting smoking, limiting alcohol consumption, and maintaining a healthy body weight to reduce the risk of chronic diseases and promote overall health. However, either instead of or in addition to engaging in some of the scientifically based recommendations, many individuals choose to use forms of Complementary and Alternative Medicine (CAM) to prevent or treat health related conditions. Some CAM modalities are safe and effective, some are potentially unsafe and effective, some are neutral, and others are potentially dangerous. Another issue is lack of patient disclosure to primary care providers regarding CAM use, which can result in complications from drug interactions, toxicities and/or other undesired effects. This study categorized CAM as safe and effective, unsafe and effective, neutral, and unsafe and ineffective; examined the use of safe and unsafe CAM therapies among a national sample of adults; identified the top three self-reported CAM modalities among a national sample of adults; and identified factors associated with patient disclosure for the top three self-reported CAM modalities. Additionally, this study ascertained the reported reasons for the use of the top three self-reported CAM modalities and determined which predisposing, enabling, need, and health behavior practices were related to CAM use among a national sample of adults. Data were extracted from the 2012 National Health Interview Survey (NHIS), and the Sociobehavioral Model of CAM Use (SBM of CAM Use) served as the theoretical framework. Hierarchical log-linear regression was used to identify factors that influence determinants for the use of safe and unsafe CAM among a national sample of adults. Out of the 34,525 adults included in analysis, 75% of participants identified as White, 15% identified as AA, and 17% identified as Hispanic, and the average age of participants was 49 years old (M=48.53, SD=18.165). Chi-square analysis revealed small meaningfully significant associations in the predisposing, enabling, need, and health behavior practices for the use of safe, potentially unsafe, and neutral CAM. Specifically, significant differences in the use of a practitioner for acupuncture, chiropractic or osteopathic manipulation, massage and the use yoga, tai chi, and qi gong were associated with age (p <.001); sex was associated with yoga, tai chi, and qi gong; marital status and age (when combined) were significant predictors for the use of multi-vitamin or mineral supplements (p <.001). Educational attainment emerged as a significant predictor for the use of relaxation techniques, yoga, tai chi, and qi gong (p <.001). Income and perceived need were meaningfully significant predictors for the use of a practitioner for massage (p <.001), and alcohol status and physical activity were predictors for the use of a practitioner for massage and the use of relaxation techniques, yoga, tai chi, and qi gong (p <.001). Findings from this study provide new information on factors in the predisposing, enabling, need, and health behavior practices that influence the use safe and unsafe CAM therapies among a national sample of adults. Health educators, healthcare providers, and other health professionals need to be educated on the types of CAM modalities, and the associated risks and benefits so accurate information can be disseminated to target populations. Furthermore, education and/or training on the use of CAM in schools of nursing, nutrition, medicine, pharmacy, public health, and other allied health professions are needed so improvement in the disclosure of CAM can occur between patient and healthcare professionals.