Chemical Structure Data File for J.D. Ha's dissertation, "Total synthesis of clavepictines A and B"
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| dc.contributor.author | Scalfani, Vincent F. | |
| dc.date.accessioned | 2018-02-09T16:15:58Z | |
| dc.date.available | 2018-02-09T16:15:58Z | |
| dc.date.issued | 2018 | |
| dc.identifier.uri | http://ir.ua.edu/handle/123456789/3464 | |
| dc.description | This Structure Data File (sdf) is associated with the dissertation by J. Ha (http://library.ua.edu/vwebv/holdingsInfo?bibId=1053962). It was generated by the University of Alabama Libraries. The .sdf file is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). | en_US |
| dc.description | Chemical Structure Data Files can be viewed/processed with most cheminformatics toolkits and stand-alone software packages: See https://en.wikipedia.org/wiki/Cheminformatics_toolkits | |
| dc.description | This sdf file supports the research found in Ha's dissertation. Its abstract states: "The stereocontrolled total synthesis of clavepictines A and B has been accomplished in an enantioselective fashion, which has unequivocally established the absolute configuration of clavepictines A and B. The pivotal step in the synthesis is diastereoselective silver(I)-promoted cyclization of δ-amino allenes. Another key method includes cross-coupling of enol triflates of N-acyl lactams, which allows stereocontrolled functionalization of otherwise unreactive lactams under mild conditions. The utility of Beak's α-lithiation-substitution chemistry of N-BOC piperidines involving a functionalized aldehyde as the electrophile is demonstrated in the preparation of highly substituted nitrogen heterocycles. These new synthetic strategies should be of general synthetic utility in the stereoselective synthesis of quinolizidines, indolizidines, and related aza-heterocycles. Also included is the unique conformational preference of the highly substituted cis-quinolizidine core of clavepictines; the (superfluous) m-(trifluoromethyl)benzoate substituent has a surprisingly significant influence on the relative energies of the two possible chair-chair conformations." | en_US |
| dc.publisher | University of Alabama Libraries | |
| dc.relation.isbasedon | Ha, J.D. Total Synthesis of Clavepictines A and B. Ph.D. Dissertation, The University of Alabama, 1999. | |
| dc.relation.uri | http://library.ua.edu/vwebv/holdingsInfo?bibId=1053962 | |
| dc.title | Chemical Structure Data File for J.D. Ha's dissertation, "Total synthesis of clavepictines A and B" | en_US |
| dc.type | chemical/x-mdl-sdfile | |
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| local.SDFPubChemExternalIDs.URL | https://pubchem.ncbi.nlm.nih.gov/source/15645 |
