A genetic and neurochemical analysis of dopamine regulation in drosophila melanogaster of human neurodegenerative disorders and neuroinflammation

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dc.contributor Caldwell, Kim A.
dc.contributor Yoder, John H.
dc.contributor Jenny, Matthew J.
dc.contributor Pandey, Udai
dc.contributor.advisor O'Donnell, Janis M.
dc.contributor.author Ajjuri, Rami Rifat
dc.date.accessioned 2017-04-26T14:24:32Z
dc.date.available 2017-04-26T14:24:32Z
dc.date.issued 2015
dc.identifier.other u0015_0000001_0002202
dc.identifier.other Ajjuri_alatus_0004D_12497
dc.identifier.uri http://ir.ua.edu/handle/123456789/3050
dc.description Electronic Thesis or Dissertation
dc.description.abstract Dopamine, a critical neurotransmitter, regulates dozens of vital biological functions within the human brain and throughout the body, and therefore disruptions in dopamine signaling result in a wide range of behavioral, psychological and movement-related disorders. In this report, we evaluate the role of dopamine production and trafficking in two of the most common neurological movement disorders, Parkinson’s disease and Torsion Dystonia. As we age, a naturally occurring process known as neurodegeneration results in the gradual loss of neuron structure and function over time. Due to this compromised cellular integrity, neurons become considerably more susceptible to oxidative stress, mitochondrial damage, and protein misfolding and aggregation. In Parkinson’s disease and many other neurodegenerative disorders, aging remains the greatest factor contributing to disease onset. In both Parkinson’s disease and Dystonia, dopamine regulation is significantly altered, causing severe motor and mobility defects. Here, we use the model system Drosophila melanogaster to investigate genetic, environmental and dietary factors contributing to the disruption of dopamine signaling and transmission. We also present a novel method for the quantification of cellular signals related to neuroinflammation, a sophisticated immune cascade activated in the central nervous system in response to neuron stress or damage. Our work has not only proved robust evidence for the validation of our previously published results, but has also introduced novel genetic interactions and molecular pathway that strongly influence the development and progression of Parkinson’s disease and Dystonia pathology. More broadly, these findings contribute new insight into the mechanistic networks contributing to the general understanding of dopamine regulation and disorders.
dc.format.extent 171 p.
dc.format.medium electronic
dc.format.mimetype application/pdf
dc.language English
dc.language.iso en_US
dc.publisher University of Alabama Libraries
dc.relation.ispartof The University of Alabama Electronic Theses and Dissertations
dc.relation.ispartof The University of Alabama Libraries Digital Collections
dc.relation.hasversion born digital
dc.rights All rights reserved by the author unless otherwise indicated.
dc.subject.other Molecular biology
dc.subject.other Biology
dc.subject.other Genetics
dc.title A genetic and neurochemical analysis of dopamine regulation in drosophila melanogaster of human neurodegenerative disorders and neuroinflammation
dc.type thesis
dc.type text
etdms.degree.department University of Alabama. Dept. of Biological Sciences
etdms.degree.discipline Biological Sciences
etdms.degree.grantor The University of Alabama
etdms.degree.level doctoral
etdms.degree.name Ph.D.

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