Cancer patients are at risk for depression due to the nature of their disease. Previous investigations indicate patients meeting screening criteria for depression may be underdiagnosed or undertreated for their symptoms. For cancer patients, psychological distress may exacerbate pain, increase desire for hastened death, and increase disability. A randomized controlled trial (RCT) design was employed to determine feasibility and efficacy of a one-time, in-person psychoeducation and depression literacy intervention by comparing it to a treatment as usual (TAU) control group. Outpatient palliative care patients were eligible with PHQ-9 score ≥5, cancer diagnosis, absence of SMI or cognitive impairment, 19 years or older, able to speak and understand English, and available to be reached and communicate by telephone. Baseline and one month follow-up telephone assessments used vignettes and questionnaires to assess depression literacy, psychological distress, and disability. Forty-three patients enrolled, majority white (65%) females (75%) with mean age of 48 years (SD= 11.08). Three intervention participants dropped out before completing the intervention visit and follow-up interview; therefore, 40 participants were included in analysis. Group differences were controlled using propensity score. Intervention participants demonstrated clinically relevant change in depression literacy including: symptom identification (OR=2.0, 95%CI=0.296-13.511), likelihood to seek MH care with counselors (OR=4.059, 95%CI=0.388-42.491), psychiatrists (OR=4.2, 95%CI=0.397-44.4), and social workers (OR=4.2, 95%CI=0.397-44.401), and improved perceptions toward employees (OR=2.556, 95%CI=0.214-30.469) and parents (OR=15.333, 95%CI=1.711-137.404) with severe depression. Decreased somatic complaints (M=-1.7, SE=1.68, d=-0.378) and more stable level of disability were also found (M=-3.0, SE=3.36, d=-0.319). Although results are promising, future studies with more participants, improved outcome measurement, and diversity in the sample are warranted to improve the understanding of the magnitude of change in depression literacy between groups, and improve the generalizability of findings. Integration of the intervention across time, within the clinical setting may increase uptake and completion of the intervention. Also, long term follow-up would allow researchers to track the effect of the intervention on help-seeking behaviors.