The rapid growth of globalization and the interconnectedness among nations challenges universities to transform their educational practices and integrate an international perspective through internationalization of their campuses. How an institution advances internationalization efforts to provide all students with the intercultural skills, increased cultural awareness and expanded worldviews necessary to help them succeed in today's global society depends on the support of the organizational culture and its commitment to implement needed change. The purpose of this study was to examine the relationship between organizational culture/change and internationalization efforts at one research institution through a qualitative, descriptive case study. Tierney's (1988) framework on the Six Concepts of Culture and Kezar and Eckel's (2002) framework on Five Change Strategies were used to analyze data from senior leadership, administrators, faculty and students to explore how organizational culture and change supported or deterred internationalization efforts at one institution.