Magnetic heating of Fe3O4 nanoparticles and magnetic micelles for a magnetothermally-triggered drug delivery system for cancer therapy

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dc.contributor Brazel, Christopher S.
dc.contributor Bao, Yuping
dc.contributor Nikles, David E.
dc.contributor.advisor Brazel, Christopher S.
dc.contributor.author Bennett, James Brandon
dc.date.accessioned 2017-03-01T16:25:16Z
dc.date.available 2017-03-01T16:25:16Z
dc.date.issued 2012
dc.identifier.other u0015_0000001_0000868
dc.identifier.other Bennett_alatus_0004M_10990
dc.identifier.uri https://ir.ua.edu/handle/123456789/1369
dc.description Electronic Thesis or Dissertation
dc.description.abstract Magnetic nanoparticles, MNPs, combined with stimuli-responsive polymers show potential to enhance the efficacy of cancer therapy in multifunctional nanoscale drug delivery systems. This project investigates the use of iron oxide nanoparticles (magnetite) to generate heat, via an applied magnetic field, to stimulate drug release of doxorubicin from an RGD-peptide targeted thermo-sensitive poly (ethylene glycol)-b-poly (caprolactone) micelle. Fe_3 O_4; nanoparticles custom synthesized at UA show the ability to heat to temperatures adequate for melting a semi-crystalline poly (caprolactone) micelle core. Investigations into parameters effecting magnetic heating of Fe_3 O_4 included studying the effects of magnetic field strength, H, and frequency, f. The results showed magnetic heating of the MNPs could induce hyperthermic temperatures. Specific absorption rates (SAR) for the MNPs were in the range of previously reported magnetite SARs, and followed the relationship with magnetic field strength predicted by the Rosensweig equation. The internal energy change in magnetic micelles was larger than that observed for MNPs in hexane when heated by an AC magnetic field. Drug release studies using triamterene- and doxorubicin- loaded micelles show a temperature-dependent acceleration of drug release at temperatures above 42 °C, the melting point of poly (caprolactone), as well as the possibility of magnetic induction hyperthermia-activated release.
dc.format.extent 96 p.
dc.format.medium electronic
dc.format.mimetype application/pdf
dc.language English
dc.language.iso en_US
dc.publisher University of Alabama Libraries
dc.relation.ispartof The University of Alabama Electronic Theses and Dissertations
dc.relation.ispartof The University of Alabama Libraries Digital Collections
dc.relation.hasversion born digital
dc.rights All rights reserved by the author unless otherwise indicated.
dc.subject.other Chemical engineering
dc.subject.other Biomedical engineering
dc.title Magnetic heating of Fe3O4 nanoparticles and magnetic micelles for a magnetothermally-triggered drug delivery system for cancer therapy
dc.type thesis
dc.type text
etdms.degree.department University of Alabama. Dept. of Chemical and Biological Engineering
etdms.degree.discipline Chemical & Biological Engineering
etdms.degree.grantor The University of Alabama
etdms.degree.level master's
etdms.degree.name M.S.


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