Browsing by Author "Edison, Arthur S."
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Considerations when choosing a genetic model organism for metabolomics studies(Elsevier, 2017) Reed, Laura K.; Baer, Charles F.; Edison, Arthur S.; University of Alabama Tuscaloosa; University of Florida; University of GeorgiaModel organisms are important in many areas of chemical biology. In metabolomics, model organisms can provide excellent samples for methods development as well as the foundation of comparative phylometabolomics, which will become possible as metabolomics applications expand. Comparative studies of conserved and unique metabolic pathways will help in the annotation of metabolites as well as provide important new targets of investigation in biology and biomedicine. However, most chemical biologists are not familiar with genetics, which needs to be considered when choosing a model organism. In this review we summarize the strengths and weaknesses of several genetic systems, including natural isolates, recombinant inbred lines, and genetic mutations. We also discuss methods to detect targets of selection on the metabolome.Item The Time Is Right to Focus on Model Organism Metabolomes(MDPI, 2016) Edison, Arthur S.; Hall, Robert D.; Junot, Christophe; Karp, Peter D.; Kurland, Irwin J.; Mistrik, Robert; Reed, Laura K.; Saito, Kazuki; Salek, Reza M.; Steinbeck, Christoph; Sumner, Lloyd W.; Viant, Mark R.; University of Georgia; Wageningen University & Research; CEA; UDICE-French Research Universities; Universite Paris Saclay; SRI International; Yeshiva University; Albert Einstein College of Medicine; University of Alabama Tuscaloosa; RIKEN; Chiba University; Wellcome Trust Sanger Institute; European Molecular Biology Laboratory (EMBL); University of Missouri Columbia; University of BirminghamModel organisms are an essential component of biological and biomedical research that can be used to study specific biological processes. These organisms are in part selected for facile experimental study. However, just as importantly, intensive study of a small number of model organisms yields important synergies as discoveries in one area of science for a given organism shed light on biological processes in other areas, even for other organisms. Furthermore, the extensive knowledge bases compiled for each model organism enable systems-level understandings of these species, which enhance the overall biological and biomedical knowledge for all organisms, including humans. Building upon extensive genomics research, we argue that the time is now right to focus intensively on model organism metabolomes. We propose a grand challenge for metabolomics studies of model organisms: to identify and map all metabolites onto metabolic pathways, to develop quantitative metabolic models for model organisms, and to relate organism metabolic pathways within the context of evolutionary metabolomics, i. e., phylometabolomics. These efforts should focus on a series of established model organisms in microbial, animal and plant research.