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Browsing by Author "Baines, Joel D."

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    Deletion of U(L)21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle
    (American Society of Microbiology, 2012) Mbong, Ekaette F.; Woodley, Lucille; Frost, Elizabeth; Baines, Joel D.; Duffy, Carol; University of Alabama Tuscaloosa; Cornell University
    The herpes simplex virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U(L)21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of U(L)21 results in a delay early in the HSV-1 replication cycle.